Congenital rubella: Difference between revisions

Revision as of 18:14, 20 August 2020

Transplacental transfer of rubella virus occurs during viremia, which peaks about 5 to 7 days following infection of mother
- Mother may be asymptomatic

Spectrum of disease, which includes intra-uterine fetal demise, preterm delivery, and the congenital rubella syndrome
Severity depends in part on timing of infection
- Up to 8 weeks gestation: 20% chance of spontaneous abortion
- Up to 10 weeks: 90% chance of congenital rubella syndrome (severe defects)
- 13-18 weeks: 10-20% chance of hearing loss and retinopathy
- Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
- Intra-uterine growth restriction is likely only effect in third trimester
Most children are asymptomatic at birth, but can develop signs and symptoms after several years

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 * Most children are asymptomatic at birth, but can develop signs and symptoms after several years
-=== Congenital rubella syndrome ===
+=== Congenital Rubella Syndrome ===
 * [[Causes::Sensorineural hearing loss]] (most common findings), blueberry muffin rash (from extramedullary hematopoiesis), [[Causes::cataracts]], [[Causes::glaucoma]], [[Causes::congenital heart disease]], and [[Causes::cognitive defects]]
 * [[Causes::Low birth weight]], [[Causes::thrombocytopenic purpura]], [[Causes::hepatosplenomegaly]], [[Causes::meningoencephalitis]], [[Causes::retinopathy]], [[Causes::patent ductus arteriosus]], [[Causes::pulmonary stenosis]], developmental disorders, [[Causes::cryptorchidism]], inguinal hernia
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 [[Category:Pediatrics]]
+[[Category:Congenital infections]]
 [[Category:RNA viruses]]