Congenital CMV: Difference between revisions
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**Higher in childcare workers |
**Higher in childcare workers |
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*Risk of transmission to fetus |
*Risk of transmission to fetus |
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**About 1 in 200 live births in US |
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**'''Primary infection''': 30% risk of congenital CMV; higher risk later in pregnancy, but worse outcomes earlier |
**'''Primary infection''': 30% risk of congenital CMV; higher risk later in pregnancy, but worse outcomes earlier |
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**Non-primary |
**Non-primary |
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Revision as of 00:34, 14 July 2020
Epidemiology
- Maternal seroconversion in about 2% of pregnancies
- Higher in childcare workers
- Risk of transmission to fetus
- About 1 in 200 live births in US
- Primary infection: 30% risk of congenital CMV; higher risk later in pregnancy, but worse outcomes earlier
- Non-primary
- Reinfection: 5% risk
- Reactivation: 1% risk
Clinical Presentation
- Mother may have had asymptomatic infection
- At birth
- Later
- Cognitive deficits (7%)
- Sensorineural hearing loss (20%)
Diagnosis
- In mom, IgM antibodies
- In baby, urine PCR within 2 weeks of birth
Management
- Treatment is indicated for symptomatic babies
- Brain
- Hearing
- Eye
- IV ganciclovir or PO valganciclovir, for 6 months
- Monitor CBC while on therapy
