Mpox virus: Difference between revisions
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= Microbiology = |
== Microbiology == |
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* Monkeypox virus (MPXV) is in the genus ''Orthopoxvirus'' and family ''Poxviridae'' |
* Monkeypox virus (MPXV) is in the genus ''Orthopoxvirus'' and family ''Poxviridae'' |
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= Epidemiology = |
== Epidemiology == |
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* Zoonotic disease endemic to west and central Africa |
* Zoonotic disease endemic to west and central Africa |
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* Human-to-human transmission possible, but less than smallpox |
* Human-to-human transmission possible, but less than smallpox |
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= Clinical Presentation = |
== Clinical Presentation == |
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* Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy |
* Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy |
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* Mortality 1-10% (per WHO) |
* Mortality 1-10% (per WHO) |
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= Management = |
== Management == |
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== Post-exposure prophylaxis == |
=== Post-exposure prophylaxis === |
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* ??smallpox vaccine?? |
* ??smallpox vaccine?? |
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Revision as of 11:17, 16 August 2019
Microbiology
- Monkeypox virus (MPXV) is in the genus Orthopoxvirus and family Poxviridae
Epidemiology
- Zoonotic disease endemic to west and central Africa
- Hosts include non-human primates and prairie dogs, squirrels, and possibly other rodents
- Endemic countries include DRC (most common), Liberia, Ivory Coast, Sierra Leone, Nigeria, Benin, Cameroon, Gabon, and South Sudan
- Human infection is associated with animal trapping, hunting, and skinning, and other exposures to animals including bites, feces, urine, or respiratory droplets
- Global outbreaks may happen with the global trafficking in exotic pets
- Human-to-human transmission possible, but less than smallpox
Clinical Presentation
- Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy
- Incubation period about 12 days
- Fever, rash, lymphadenopathy (cervical, submandibular, and sublingual)
- Mortality 1-10% (per WHO)
Management
Post-exposure prophylaxis
- ??smallpox vaccine??
References
- ^ Emily A Siegrist, Joseph Sassine. Antivirals With Activity Against Mpox: A Clinically Oriented Review. Clinical Infectious Diseases. 2022;76(1):155-164. doi:10.1093/cid/ciac622.
