Cyanide toxicity: Difference between revisions
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* Blocks the electron transport chain (ETC) complex 4, resulting in increased anaerobic metabolism |
* Blocks the electron transport chain (ETC) complex 4, resulting in increased anaerobic metabolism |
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== Clinical |
== Clinical Manifestations == |
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* Inhalation exposure with high lactate and venous hyperoxia |
* Inhalation exposure with high lactate and venous hyperoxia |
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Latest revision as of 00:53, 22 July 2020
Pathophysiology
- Blocks the electron transport chain (ETC) complex 4, resulting in increased anaerobic metabolism
Clinical Manifestations
- Inhalation exposure with high lactate and venous hyperoxia
- Headache
- Nausea/vomiting
- Tachycardia
- Confusion
- Seizures
- Flushing more than cyanosis
Investigations
- Laboratory
- Lactate will be high
Management
- Resuscitation
- Decontamination
- Hydroxycobalamin 5g IV x1, repeated if severe
- Sodium thiosulfate 12.5g IV x1
- Last-line: sodium nitrite
- Co-exposures
