Calcium channel blocker toxicity: Difference between revisions
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* Blocks L-type calcium channels, including in pancreas. |
* Blocks L-type calcium channels, including in pancreas. |
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== Clinical |
== Clinical Manifestations == |
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* Hypotension and bradycardia |
* Hypotension and bradycardia |
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Latest revision as of 23:43, 14 July 2020
Pathophysiology
- Blocks L-type calcium channels, including in pancreas.
Clinical Manifestations
- Hypotension and bradycardia
- Hyperglycemia from effect on pancreas (which differentiates from beta-blocker overdose that is often hypoglycemic)
Management
- Intubate early
- Call the Poison Centre
- High dose insulin euglycemic therapy
- Humulin R at 0.5-1 U/kg/hr
- Can also try intralipid
- Can also try atropine for bradycardia, sodium bicarb
