Leukemoid reaction: Difference between revisions
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==Background== |
==Background== |
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+ | |||
− | * |
+ | *Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy |
− | ** |
+ | **e.g. WBC ≥30-50 with ≥50% granulocytes |
==Differential Diagnosis== |
==Differential Diagnosis== |
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+ | |||
− | * |
+ | *'''Infections''' |
− | ** |
+ | **[[Sepsis]], [[pneumonia]], [[urinary tract infection]] |
− | ** |
+ | **''[[Clostridioides difficile]]'' colitis (often quite high) |
− | ** Disseminated [[tuberculosis]] |
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− | ** |
+ | **Disseminated [[tuberculosis]] |
+ | **Severe [[shigellosis]] |
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− | ** |
+ | **Postpartum ''[[Clostridium sordellii]]'' |
− | * |
+ | *'''Inflammation''' |
− | ** |
+ | **[[Pancreatitis]] |
− | ** |
+ | **Mesenteric inflammatory pseudotumor |
− | * |
+ | *'''Malignancies''' |
− | ** |
+ | **Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary) |
− | ** |
+ | **[[Hodgkin lymphoma]] |
− | ** |
+ | **[[Melanoma]] |
− | ** |
+ | **[[Sarcoma]] |
− | * |
+ | *'''Drugs''' |
− | ** |
+ | **[[Corticosteroids]] |
− | ** |
+ | **[[Minocycline]] |
− | ** |
+ | **Recombinant hematopoietic growth factors |
− | * |
+ | *'''Miscellaneous''' |
− | ** |
+ | **[[Splenectomy]] |
− | ** |
+ | **[[Ethylene glycol intoxication]] |
− | ** |
+ | **Severe hemorrhage or acute [[hemolysis]] |
− | ** |
+ | **[[Alcoholic steatohepatitis]] |
==Further Reading== |
==Further Reading== |
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− | * Leukemoid reaction: Spectrum and prognosis of 173 adult patients. ''Clin Infect Dis''. 2013;57:e177. doi: [https://doi.org/10.1093/cid/cit562 10.1093/cid/cit562] |
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− | * |
+ | *Leukemoid reaction: Spectrum and prognosis of 173 adult patients. ''Clin Infect Dis''. 2013;57:e177. doi: [https://doi.org/10.1093/cid/cit562 10.1093/cid/cit562] |
+ | *An update on the etiology and diagnostic evaluation of a leukemoid reaction. ''Eur J Internal Med''. 2006 Oct;17(6):394-8. doi: [https://doi.org/10.1016/j.ejim.2006.04.004 10.1016/j.ejim.2006.04.004] |
Revision as of 12:43, 26 August 2020
Background
- Significant leukocytosis and neutrophilia in the absence of a hematologic malignancy
- e.g. WBC ≥30-50 with ≥50% granulocytes
Differential Diagnosis
- Infections
- Sepsis, pneumonia, urinary tract infection
- Clostridioides difficile colitis (often quite high)
- Disseminated tuberculosis
- Severe shigellosis
- Postpartum Clostridium sordellii
- Inflammation
- Pancreatitis
- Mesenteric inflammatory pseudotumor
- Malignancies
- Carcinomas (lung, oropharyngeal, gastrointestinal, genitourinary)
- Hodgkin lymphoma
- Melanoma
- Sarcoma
- Drugs
- Corticosteroids
- Minocycline
- Recombinant hematopoietic growth factors
- Miscellaneous
- Splenectomy
- Ethylene glycol intoxication
- Severe hemorrhage or acute hemolysis
- Alcoholic steatohepatitis
Further Reading
- Leukemoid reaction: Spectrum and prognosis of 173 adult patients. Clin Infect Dis. 2013;57:e177. doi: 10.1093/cid/cit562
- An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Internal Med. 2006 Oct;17(6):394-8. doi: 10.1016/j.ejim.2006.04.004
References
- ^ Vissaria Sakka, Sotirios Tsiodras, Evangelos J. Giamarellos-Bourboulis, Helen Giamarellou. An update on the etiology and diagnostic evaluation of a leukemoid reaction. European Journal of Internal Medicine. 2006;17(6):394-398. doi:10.1016/j.ejim.2006.04.004.