Fluconazole: Difference between revisions
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* Best side effect profiles of the antifungals |
* Best side effect profiles of the antifungals |
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* Before starting, check: |
* Before starting, check: |
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** Liver enzymes as baseline ([[Adverse drug reaction::hepatitis]] |
** Liver enzymes as baseline ([[Adverse drug reaction::hepatitis]]) |
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** Creatinine (requires renal dosing) |
** Creatinine (requires renal dosing) |
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** EKG ([[Adverse drug reaction::QTc prolongation]]) |
** EKG ([[Adverse drug reaction::QTc prolongation]]) |
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Revision as of 03:15, 18 February 2020
Classification
- Antifungal in the triazole family with excellent bioavadilability but limited efficacy outside of Candida
Indications
- Fungal infections
Monitoring
- ECG for QT prolongation
- Liver enzymes for hepatitis
Pharmacokinetics
- Good oral bioavailability
- CNS penetration
Adverse Drug Reactions
- Best side effect profiles of the antifungals
- Before starting, check:
- Liver enzymes as baseline (hepatitis)
- Creatinine (requires renal dosing)
- EKG (QTc prolongation)
- Beware drug-drug interactions, especially with new DOACs
