Post-transplant acute limbic encephalitis: Difference between revisions

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== Background ==
 
== Background ==
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* Caused by [[HHV-6]]
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* Caused by [[HHV-6B]]
   
 
== Clinical Presentation ==
 
== Clinical Presentation ==

Revision as of 20:03, 10 February 2020

  • Limbic encephalitis syndrome following hematopoietic stem cell transplantation

Background

Clinical Presentation

  • Onset 2 weeks to 2 months after transplant
  • Presents with confusion, amnesia, hallucinations
  • Can cause seizures
  • Hyponatremia is common

Management

  • Treat seizures with antiepileptic medications
  • Treat any possible concomitant risk factors such as hyponytremia
  • Antivirals: acyclovir, ganciclovir, or foscarnet for 10 days to 4 weeks

References

  1. ^  Joseph Ongrádi, Dharam V. Ablashi, Tetsushi Yoshikawa, Balázs Stercz, Masao Ogata. Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals. Journal of NeuroVirology. 2016;23(1):1-19. doi:10.1007/s13365-016-0473-0.