Congenital rubella: Difference between revisions
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== Background == |
== Background == |
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=== Pathophysiology === |
=== Pathophysiology === |
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* Transplacental transfer of virus occurs during viremia, which peaks about 5 to 7 days following infection of mother |
* Transplacental transfer of [[Rubella virus]] occurs during viremia, which peaks about 5 to 7 days following infection of mother |
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== Clinical Presentation == |
== Clinical Presentation == |
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Revision as of 01:44, 9 February 2020
Background
Pathophysiology
- Transplacental transfer of Rubella virus occurs during viremia, which peaks about 5 to 7 days following infection of mother
Clinical Presentation
- Spectrum of disease, which includes intra-uterine fetal demise, preterm delivery, and the congenital rubella syndrome
- Severity depends in part on timing of infection
- Infection in first trimester has 80% chance of defects
- Congenital defects are unlikely if infection happens after 18 to 20 weeks gestation
- Intra-uterine growth restriction is likely only effect in third trimester
- Most children are asymptomatic at birth, but can develop signs and symptoms after several years
- Deafness, cataracts, glaucoma, congenital heart disease, and cognitive defects
- Low birth weight, thrombocytopenic purpura, hepatosplenomegaly, meningoencephalitis, retinopathy, patent ductus arteriosus, pulmonary stenosis, developmental disorders, cryptorchidism, inguinal hernia
- By the second decade of life, it can cause a progressing, fatal panencephalitis
