Single-tablet regimens for HIV: Difference between revisions
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| Triumeq |
| Triumeq |
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| abacavir / lamivudine |
| [[abacavir]] / [[lamivudine]] |
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| dolutegravir (INI) |
| [[dolutegravir]] (INI) |
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| Highest barrier to resistance. Need to test for HLA-B5701 allele before starting. Avoid in hepatitis B coinfection. |
| Highest barrier to resistance. Need to test for HLA-B5701 allele before starting. Avoid in hepatitis B coinfection. |
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| Atripla |
| Atripla |
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| tenofovir disoproxil / emtricitabine |
| [[tenofovir disoproxil fumarate]] / [[emtricitabine]] |
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| efavirenz |
| [[efavirenz]] |
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| Older regimen. Neuropsychiatric symptoms, possibly including suicide. |
| Older regimen. Neuropsychiatric symptoms, possibly including suicide. |
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| Complera |
| Complera |
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| tenofovir disoproxil / emtricitabine |
| [[tenofovir disoproxil fumarate]] / [[emtricitabine]] |
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| rilpivirine |
| [[rilpivirine]] |
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| Avoid with viral loads (>100,000) or low CD4 (<200). Pill must be taken with food (>400kcal) and without PPIs. |
| Avoid with viral loads (>100,000) or low CD4 (<200). Pill must be taken with food (>400kcal) and without PPIs. |
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| Stribild |
| Stribild |
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| tenofovir disoproxil / emtricitabine |
| [[tenofovir disoproxil fumarate]] / [[emtricitabine]] |
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| elvitegravir/cobicistat (INI) |
| [[elvitegravir]]/[[cobicistat]] (INI) |
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| Includes a P450 inhibitor to boost elvitegravir levels, with resultant drug-drug interactions. Avoid if CrCl <70. |
| Includes a P450 inhibitor to boost elvitegravir levels, with resultant drug-drug interactions. Avoid if CrCl <70. |
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| Genvoya |
| Genvoya |
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| tenofovir alafenamide / emtricitabine |
| [[tenofovir alafenamide]] / [[emtricitabine]] |
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| elvitegravir/cobicistat (INI) |
| [[elvitegravir]]/[[cobicistat]] (INI) |
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| See Stribild, above. |
| See Stribild, above. |
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| Biktarvy |
| Biktarvy |
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| tenofovir alafenamide / emtricitabine |
| [[tenofovir alafenamide]] / [[emtricitabine]] |
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| bictegravir (INI) |
| [[bictegravir]] (INI) |
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Revision as of 01:44, 22 January 2020
See also HIV treatment
| Brand name | NRTIs | Non-NRTI | Notes |
|---|---|---|---|
| Triumeq | abacavir / lamivudine | dolutegravir (INI) | Highest barrier to resistance. Need to test for HLA-B5701 allele before starting. Avoid in hepatitis B coinfection. |
| Atripla | tenofovir disoproxil fumarate / emtricitabine | efavirenz | Older regimen. Neuropsychiatric symptoms, possibly including suicide. |
| Complera | tenofovir disoproxil fumarate / emtricitabine | rilpivirine | Avoid with viral loads (>100,000) or low CD4 (<200). Pill must be taken with food (>400kcal) and without PPIs. |
| Stribild | tenofovir disoproxil fumarate / emtricitabine | elvitegravir/cobicistat (INI) | Includes a P450 inhibitor to boost elvitegravir levels, with resultant drug-drug interactions. Avoid if CrCl <70. |
| Genvoya | tenofovir alafenamide / emtricitabine | elvitegravir/cobicistat (INI) | See Stribild, above. |
| Biktarvy | tenofovir alafenamide / emtricitabine | bictegravir (INI) |
