Pseudomonas aeruginosa: Difference between revisions
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Pseudomonas aeruginosa
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== Treatment == |
== Treatment == |
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* Refer to [[antipseudomonal antibiotics]] for specific treatment options |
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* Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection |
* Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection |
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Revision as of 15:07, 24 October 2019
Background
Microbiology
- Oxidase-positive, non-fermenting Gram-negative bacillus
Mechanisms of Resistance
- Broad intrinsic and acquired antibiotic resistance
- Membrane impermeability
- MexAB-OprM efflux pump
- Acquired mutations
- Inducible AmpC β-lactamase
- Plasmid sharing
Epidemiology
- Loves moist and wet environments
- Causes healthcare-associated infections
- UTI, SSI, bacteremia, HAP, VAP
- Especially common in cystic fibrosis
Treatment
- Refer to antipseudomonal antibiotics for specific treatment options
- Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection
References
- ^ D. M. Livermore. Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?. Clinical Infectious Diseases. 2002;34(5):634-640. doi:10.1086/338782.
