Valganciclovir: Difference between revisions

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== Background ==
* Valine ester of [[ganciclovir]] with much higher oral bioavailability (70%)
* Valine ester of [[ganciclovir]] with much higher oral bioavailability (70%)
* Indications: {{#ask: [[Is treated by::valganciclovir]] | default=none}}
* Indications: {{#ask: [[Is treated by::valganciclovir]] | default=none}}

== Dosing ==

* [[CMV after solid organ transplantation|CMV prophylaxis in solid organ transplant]]: 900 mg p.o. daily
* Mild-to-moderate [[CMV after solid organ transplantation|CMV disease in solid organ transplant]]: 900 mg p.o. twice daily
* [[CMV after hematopoietic stem cell transplantation|CMV viremia in hematopoietic stem cell transplant]]: 900 mg p.o. twice daily for 7 to 14 days followed by once daily until negative PCR

=== Renal Dosing ===
{| class="wikitable"
!CrCl
!Induction or Treatment
!Maintenance or Prophylaxis
|-
|≥60
|900 mg twice daily
|900 mg once daily
|-
|40 to 59
|450 mg twice daily
|450 mg once daily
|-
|25 to 39
|450 mg once daily
|450 mg every 2 days
|-
|10 to 24
|450 mg every 2 days
|450 mg twice weekly
|-
|<10
|Not recommended; may consider using oral solution 200 mg 3 times weekly
|Not recommended; may consider using oral solution 100 mg 3 times weekly
|}

== Safety ==

=== Adverse Effects ===

* Long list
* Anemia, thrombocytopenia, and neutropenia


[[Category:Antivirals]]
[[Category:Antivirals]]

Latest revision as of 21:59, 22 February 2024

Background

Dosing

Renal Dosing

CrCl Induction or Treatment Maintenance or Prophylaxis
≥60 900 mg twice daily 900 mg once daily
40 to 59 450 mg twice daily 450 mg once daily
25 to 39 450 mg once daily 450 mg every 2 days
10 to 24 450 mg every 2 days 450 mg twice weekly
<10 Not recommended; may consider using oral solution 200 mg 3 times weekly Not recommended; may consider using oral solution 100 mg 3 times weekly

Safety

Adverse Effects

  • Long list
  • Anemia, thrombocytopenia, and neutropenia