Giardia lamblia: Difference between revisions

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Giardia lamblia
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* A member of the [[Giardia species]] that causes intestinal disease in humans and animals
* A member of the [[Giardia species]] that causes intestinal disease ('''giardiasis''') in humans and animals
* Also known as '''beaver fever'''

== Microbiology ==

* Flagellated protozoan that infects the small bowel
* Host specificity related to genotype ("assemblage")
** Assemblages A & B infect humans, but also numerous non-human hosts including primates, dogs, cars, cattle, sheep, deer, rodents, horses, and beavers
** Assemblages C & D affect dogs; E affects cattle, goats, sheep, and pigs; F affects cats; G affects rodents; and H affects marine vertebrates
* Antigenic variation is determined by the variant-specific surface protein (VSP)
** Replaced every few generations

== Life Cycle ==

* A cyst is ingested via fecal-oral contamination
* In the small bowel, the cyst releases two trophozoites (free-living form) via excystation
* Trophozoites multiply by binary fission
* When they reach the large bowel, they encyst

== Epidemiology ==

* Worldwide distribution
* Numerous animal reservoirs, not fully understood how important they are
* Cysts can survive several months in cold water



{{DISPLAYTITLE:''Giardia lamblia''}}
{{DISPLAYTITLE:''Giardia lamblia''}}

Revision as of 01:04, 9 October 2019

  • A member of the Giardia species that causes intestinal disease (giardiasis) in humans and animals
  • Also known as beaver fever

Microbiology

  • Flagellated protozoan that infects the small bowel
  • Host specificity related to genotype ("assemblage")
    • Assemblages A & B infect humans, but also numerous non-human hosts including primates, dogs, cars, cattle, sheep, deer, rodents, horses, and beavers
    • Assemblages C & D affect dogs; E affects cattle, goats, sheep, and pigs; F affects cats; G affects rodents; and H affects marine vertebrates
  • Antigenic variation is determined by the variant-specific surface protein (VSP)
    • Replaced every few generations

Life Cycle

  • A cyst is ingested via fecal-oral contamination
  • In the small bowel, the cyst releases two trophozoites (free-living form) via excystation
  • Trophozoites multiply by binary fission
  • When they reach the large bowel, they encyst

Epidemiology

  • Worldwide distribution
  • Numerous animal reservoirs, not fully understood how important they are
  • Cysts can survive several months in cold water