Pseudomonas aeruginosa: Difference between revisions
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Pseudomonas aeruginosa
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== Background == |
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=== Microbiology === |
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* Oxidase-positive, non-fermenting Gram negative bacillus |
* [[Has oxidase test::Oxidase-positive]], non-fermenting [[Has Gram stain::Gram-negative]] [[Has cell shape::bacillus]] |
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* Broad intrinsic and acquired antibiotic resistance |
* Broad intrinsic and acquired antibiotic resistance |
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* Membrane impermeability |
* Membrane impermeability |
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* Plasmid sharing |
* Plasmid sharing |
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=== Epidemiology === |
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== Environment and Infections == |
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* Loves moist and wet environments |
* Loves moist and wet environments |
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* Causes healthcare-associated infections |
* Causes healthcare-associated infections |
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Revision as of 15:05, 24 October 2019
Background
Microbiology
- Oxidase-positive, non-fermenting Gram-negative bacillus
Mechanisms of Resistance
- Broad intrinsic and acquired antibiotic resistance
- Membrane impermeability
- MexAB-OprM efflux pump
- Acquired mutations
- Inducible AmpC β-lactamase
- Plasmid sharing
Epidemiology
- Loves moist and wet environments
- Causes healthcare-associated infections
- UTI, SSI, bacteremia, HAP, VAP
- Especially common in cystic fibrosis
Treatment
- See Antipseudomonal antibiotics
- Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection
References
- ^ D. M. Livermore. Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?. Clinical Infectious Diseases. 2002;34(5):634-640. doi:10.1086/338782.
