Marburg virus: Difference between revisions

Revision as of 09:38, 28 August 2020

Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
Animal reservoir is fruit bat, with a sylvian cycle that occasionally spills over into human populations
- The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa

Incubation period 2 to 21 days
Starts with high fever, severe headache malaise
Followed by multi-system involvement as early as day 3
- Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
- Chest pain, dyspnea, cough
- Hypotension, edema, maculopapular rash
- Headache, confusion
Mortality 23 to 90%

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-== Microbiology ==
+==Background==
+=== Microbiology ===
-* Negative-sense single-stranded RNA virus in the Filoviridae family
+*Negative-sense single-stranded RNA virus in the [[Filoviridae]] family
+*Genus contains two species
+**Marburg virus
+**Ravn virus
+=== Epidemiology ===
+* Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
+* Animal reservoir is [[Reservoir::fruit bat]], with a sylvian cycle that occasionally spills over into human populations
+** The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa
+== Clinical Manifestations ==
+* Incubation period [[Usual incubation period::2 to 21 days]]
+* Starts with high fever, severe headache malaise
+* Followed by multi-system involvement as early as day 3
+** Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
+** Chest pain, dyspnea, cough
+** Hypotension, edema, maculopapular rash
+** Headache, confusion
+* Mortality 23 to 90%
+== Management ==
+* Good supportive care decreases mortality substantially
+* Experimental therapies include [[favipiravir]] and monoclonal antibodies
+== Prevent ==
+* Vaccination is under investigation
 [[Category:Filoviridae]]