Marburg virus: Difference between revisions
From IDWiki
(→) |
No edit summary |
||
| Line 1: | Line 1: | ||
== |
==Background== |
||
=== Microbiology === |
|||
| ⚫ | |||
| ⚫ | |||
*Genus contains two species |
|||
**Marburg virus |
|||
**Ravn virus |
|||
=== Epidemiology === |
|||
* Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases |
|||
* Animal reservoir is [[Reservoir::fruit bat]], with a sylvian cycle that occasionally spills over into human populations |
|||
** The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa |
|||
== Clinical Manifestations == |
|||
* Incubation period [[Usual incubation period::2 to 21 days]] |
|||
* Starts with high fever, severe headache malaise |
|||
* Followed by multi-system involvement as early as day 3 |
|||
** Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week) |
|||
** Chest pain, dyspnea, cough |
|||
** Hypotension, edema, maculopapular rash |
|||
** Headache, confusion |
|||
* Mortality 23 to 90% |
|||
== Management == |
|||
* Good supportive care decreases mortality substantially |
|||
* Experimental therapies include [[favipiravir]] and monoclonal antibodies |
|||
== Prevent == |
|||
* Vaccination is under investigation |
|||
[[Category:Filoviridae]] |
[[Category:Filoviridae]] |
||
Revision as of 13:38, 28 August 2020
Background
Microbiology
- Negative-sense single-stranded RNA virus in the Filoviridae family
- Genus contains two species
- Marburg virus
- Ravn virus
Epidemiology
- Rare, with 11 outbreaks since discovery in 1967, totalling 470 cases
- Animal reservoir is fruit bat, with a sylvian cycle that occasionally spills over into human populations
- The range of the reservoir extends into Middle East, South Asia, and south Pacific, but the virus is essentially limited to subsaharan Africa
Clinical Manifestations
- Incubation period 2 to 21 days
- Starts with high fever, severe headache malaise
- Followed by multi-system involvement as early as day 3
- Nausea, vomiting, anorexia, abdominal pain, diarrhea (can persist for a week)
- Chest pain, dyspnea, cough
- Hypotension, edema, maculopapular rash
- Headache, confusion
- Mortality 23 to 90%
Management
- Good supportive care decreases mortality substantially
- Experimental therapies include favipiravir and monoclonal antibodies
Prevent
- Vaccination is under investigation
