Trypanosoma: Difference between revisions

Revision as of 15:19, 20 June 2020

Flagellated vector-borne protozoan parasite of mammals in the genus Trypanosoma
Generally have three morphological states: epimastigote, amastigote, and trypomastigote
- T. cruzi has an intracellular amastigote while T. brucei do not, but rather multiply as trypomastigotes in the bloodstream
- Amastigotes are commonly intracellular, and are small with a very short flagellum
- Epimastigotes have a flagellum that runs along and connects as an undulating membrane, with the kinetoplast anterior to the nucleus
- Trypomastigotes have a similar flagellum as epimastigotes, but with the kinetoplast posterior to the nucleus
Two major groups
- Stercoraria, which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut
  - Transferred via contaminated feces
  - e.g. Trypanosoma cruzi
- Salivaria, which multiply continuously in the mammal as trypomastigotes, and develop in the vector in the salivary glands
  - Transferred via saliva
  - e.g. Trypanosoma brucei
Three species infect humans
- Trypanosoma cruzi, which causes Chagas disease
- Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause African sleeping sickness

@@ Line 1: / Line 1: @@
-== Microbiology ==
+==Background==
+===Microbiology==
 * Flagellated vector-borne protozoan parasite of mammals in the genus ''Trypanosoma''
 * Generally have three morphological states: epimastigote, amastigote, and trypomastigote
@@ Line 7: / Line 7: @@
 ** Epimastigotes have a flagellum that runs along and connects as an undulating membrane, with the kinetoplast anterior to the nucleus
 ** Trypomastigotes have a similar flagellum as epimastigotes, but with the kinetoplast posterior to the nucleus
-[[File:800px-TrypanosomatidMorphologies_PlainSVG.svg.png|Stages of trypanosomes]]
 * Two major groups
 ** ''Stercoraria'', which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut
 *** Transferred via contaminated feces
-*** e.g. ''[[T. cruzi]]''
+*** e.g. ''[[Trypanosoma cruzi]]''
 ** ''Salivaria'', which multiply continuously in the mammal as trypomastigotes, and develop in the vector in the salivary glands
 *** Transferred via saliva
-*** e.g. ''[[T. brucei]]''
+*** e.g. ''[[Trypanosoma brucei]]''
 * Three species infect humans
-** ''[[T. cruzi]]'', which causes Chagas disease
+** ''[[Trypanosoma cruzi]]'', which causes Chagas disease
-** ''[[T. brucei gambiense]]'' and ''[[T. brucei rhodesiense]]'', which cause African sleeping sickness
+** ''[[Trypanosoma brucei gambiense]]'' and ''[[Trypanosoma brucei rhodesiense]]'', which cause African sleeping sickness
 {{DISPLAYTITLE:''Trypanosoma'' species}}