Antimicrobial desensitization: Difference between revisions
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==Background== |
==Background== |
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*Goal of creating temporary tolerance to an antimicrobial to which the patient has a history of hypersensitivity reaction |
*Goal of creating temporary tolerance to an antimicrobial to which the patient has a history of hypersensitivity reaction |
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*Best described for beta-lactam antibiotics with immediate IgE-mediated hypersensitivity reaction |
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*Must carefully evaluate risks and benefits |
*Must carefully evaluate risks and benefits |
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== Procedure == |
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* No well-defined universal procedure |
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* Most use a dilution of 0.1% or 1% of therapeutic dose as a continuous infusion (or oral, or subcut), with dose increased steadily over hours to days |
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== Further Reading == |
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* Antimicrobial Desensitization: A Review of Published Protocols. ''Pharmacy (Basel)''. 2019;7(3):112. doi: [https://doi.org/10.3390/pharmacy7030112 10.3390/pharmacy7030112]. PMID: [https://pubmed.ncbi.nlm.nih.gov/31405062/ 31405062]; PMCID: [https://pmc.ncbi.nlm.nih.gov/articles/PMC6789802/ PMC6789802]. |
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[[Category:Procedures]] |
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Revision as of 22:47, 1 January 2025
Background
- Goal of creating temporary tolerance to an antimicrobial to which the patient has a history of hypersensitivity reaction
- Best described for beta-lactam antibiotics with immediate IgE-mediated hypersensitivity reaction
- Must carefully evaluate risks and benefits
Procedure
- No well-defined universal procedure
- Most use a dilution of 0.1% or 1% of therapeutic dose as a continuous infusion (or oral, or subcut), with dose increased steadily over hours to days
Further Reading
- Antimicrobial Desensitization: A Review of Published Protocols. Pharmacy (Basel). 2019;7(3):112. doi: 10.3390/pharmacy7030112. PMID: 31405062; PMCID: PMC6789802.
