Doxycycline: Difference between revisions
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=== Adverse Effects === |
=== Adverse Effects === |
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* Counsel on high risk of sun sensitivity and pill esophagitis |
* Counsel on high risk of sun sensitivity and pill esophagitis |
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=== Pregnancy === |
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* Generally avoid using in pregnant women and children less than 8 years of age due to bone and tooth staining |
* Generally avoid using in pregnant women and children less than 8 years of age due to bone and tooth staining |
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** However, can often tolerate short courses up to 5 days without issue |
** However, can often tolerate short courses up to 5 days without issue |
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Revision as of 14:57, 1 November 2023
Background
- Tetracycline antibiotic
Spectrum of Activity
- Can treat: Actinomyces, Bacillary angiomatosis, Bartonella henselae, Borrelia miyamotoi, Brucella melitensis, Burkholderia mallei, Chlamydia trachomatis, Cutibacterium acnes, Enterococcus, Francisella tularensis, Legionella, Leptospira, Lymphogranuloma venereum, Mycoplasma genitalium, Pelvic inflammatory disease, Plasmodium, Rickettsia, Rickettsia africae, Rickettsia akari, Rickettsia conorii, Rickettsia prowazekii, Rickettsia rickettsii, Rickettsia typhi, Rickettsioses, Rickettsioses, Southern tick-associated rash illness, Stenotrophomonas maltophilia, Tick-borne relapsing fever, Treponema pallidum pallidum, Yersinia enterocolitica, Yersinia pestis
Distribution
- Achieves only low concentrations in the urine, so generally not recommended for UTIs, though some debate about this[1]
Dosing
- Usual dosing 100 mg po BID
Safety
Adverse Effects
- Counsel on high risk of sun sensitivity and pill esophagitis
Pregnancy
- Generally avoid using in pregnant women and children less than 8 years of age due to bone and tooth staining
- However, can often tolerate short courses up to 5 days without issue
- ↑ Tomasz Jodlowski, Charles R Ashby, Sarath G Nath, Doxycycline for ESBL-E Cystitis, Clinical Infectious Diseases, Volume 73, Issue 1, 1 July 2021, Pages e274–e275, https://doi.org/10.1093/cid/ciaa1898
References
- ^ Tomasz Jodlowski, Charles R Ashby, Sarath G Nath. Doxycycline for ESBL-E Cystitis. Clinical Infectious Diseases. 2020. doi:10.1093/cid/ciaa1898.
- ^ C W Yim, N M Flynn, F T Fitzgerald. Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis. Antimicrobial Agents and Chemotherapy. 1985;28(2):347-348. doi:10.1128/aac.28.2.347.
- ^ L Dotevall, L Hagberg. Penetration of doxycycline into cerebrospinal fluid in patients treated for suspected Lyme neuroborreliosis. Antimicrobial Agents and Chemotherapy. 1989;33(7):1078-1080. doi:10.1128/aac.33.7.1078.
