Drug-induced neutropenia: Difference between revisions
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(Created page with "{| class="wikitable sortable" !Class !Drug !Frequency reported !Nature of reaction |- | rowspan="7" |Antibiotics |Semisynthetic penicillins (amoxicillin, ampicillin) |Moderate |Both |- |Cephalosporins |Moderate |Both |- |Vancomycin |High |Both |- |Macrolides |Low |Neutropenia |- |TMP-SMX |High |Agranulocytosis |- |Dapsone |High |Agranulocytosis |- |Chloramphenicol |High |Agranulocytosis |- | rowspan="2" |Antifungals |Amphotericin |Low |Neutropenia |- |Flucytosine |...") |
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* Agranulocytosis refers to the complete absence of neutrophils or granulocytes (ANC of 0) |
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Revision as of 14:45, 27 February 2024
- Agranulocytosis refers to the complete absence of neutrophils or granulocytes (ANC of 0)
| Class | Drug | Frequency reported | Nature of reaction |
|---|---|---|---|
| Antibiotics | Semisynthetic penicillins (amoxicillin, ampicillin) | Moderate | Both |
| Cephalosporins | Moderate | Both | |
| Vancomycin | High | Both | |
| Macrolides | Low | Neutropenia | |
| TMP-SMX | High | Agranulocytosis | |
| Dapsone | High | Agranulocytosis | |
| Chloramphenicol | High | Agranulocytosis | |
| Antifungals | Amphotericin | Low | Neutropenia |
| Flucytosine | Low | Agranulocytosis | |
| Antimalarials | Chloroquine | Low | Agranulocytosis |
| Quinine | Moderate | Agranulocytosis | |
| Antiinflammatory agents | Ibuprofen | Low | Agranulocytosis |
| Diclofenac | Moderate | Agranulocytosis | |
| Sulfasalazine | High | Agranulocytosis | |
| Gold salts | Agranulocytosis | ||
| Antithyroid drugs | Methimazole | High | Agranulocytosis |
| Propylthiouracil | Moderate | Agranulocytosis | |
| Psychotropic agents | Clozapine | High | Agranulocytosis |
| Phenothiazines (chlorpromazine) | Moderate | Agranulocytosis | |
| Tricyclic agents (amitriptyline) | Low | Agranulocytosis | |
| Antiepileptics | Carbamazepine | Low | Neutropenia |
| Phenytoin | Moderate | Agranulocytosis | |
| Valproate | Low | Neutropenia | |
| Ethosuximide | Low | Neutropenia | |
| Cardiovascular drugs | Antiarrhythmic agents (procainamide, flecainide) | High | Agranulocytosis |
| ACE inhibitors | Moderate | Agranulocytosis | |
| Propranolol | Low | Agranulocytosis | |
| Digoxin | Moderate | Agranulocytosis | |
| Ticlopidine | High | Agranulocytosis | |
| Diuretics | Thiazides | Low | Neutropenia |
| Furosemide | Low | Neutropenia | |
| Spironolactone | Low | Agranulocytosis | |
| Acetazolamide | Low | Neutropenia | |
| Other | Deferiprone | Moderate | Agranulocytosis |
| Levamisole | Moderate | Agranulocytosis | |
| Rituximab | Moderate | Agranulocytosis |
- From [1]
- ↑ Christopher Gibson, Nancy Berliner; How we evaluate and treat neutropenia in adults. Blood 2014; 124 (8): 1251–1258. doi: https://doi.org/10.1182/blood-2014-02-482612
References
- ^ Christopher Gibson, Nancy Berliner. How we evaluate and treat neutropenia in adults. Blood. 2014;124(8):1251-1258. doi:10.1182/blood-2014-02-482612.
