Amoxicillin-clavulanic acid: Difference between revisions

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(Created page with "==Dosing== * Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily * Intravenous: 1 g IV every 8 hours, or 2 g IV every 8 to 12 hours Category:β-lactams‏‎")
 
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==Dosing==
 
==Dosing==
 
* Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
 
* Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
* Intravenous: 1 g IV every 8 hours, or 2 g IV every 8 to 12 hours
+
* Intravenous:
  +
** Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
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** High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours
   
  +
=== Renal Dosing ===
  +
{| class="wikitable"
  +
!CrCl (mL/min)
  +
!Dose
  +
|-
  +
! colspan="2" |Oral
  +
|-
  +
|>30
  +
|875/125 mg p.o. q12h
  +
|-
  +
|10-29
  +
|500/125 mg p.o. q12h
  +
|-
  +
|<10
  +
|500/125 mg p.o. q24h
  +
|-
  +
|Hemodialysis
  +
|500/125 mg p.o. q24h (given after dialysis on dialysis days)
  +
|-
  +
|Peritoneal dialysis
  +
|250/125 mg p.o. q12h
  +
|-
  +
|CRRT
  +
|Usual dose
  +
|-
  +
! colspan="2" |Intravenous
  +
|-
  +
|>30
  +
|1 g IV q8h
  +
|-
  +
|10-29
  +
|1 g IV followed by 500 mg IV q12h
  +
|-
  +
|<10
  +
|1 g IV followed by 500 mg IV q24h
  +
|-
  +
|Hemodialysis
  +
|1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days)
  +
|}
 
[[Category:β-lactams‏‎]]
 
[[Category:β-lactams‏‎]]
  +
[[Category:Β-lactamase inhibitors]]

Latest revision as of 15:21, 23 June 2023

Dosing

  • Oral: 500 mg/125 mg p.o. three times daily, or 875 mg/125 mg p.o. twice daily
  • Intravenous:
    • Usual dose: 1 g (1000 mg/ 200 mg) IV every 8 hours
    • High dose: 2 g (2000 mg/ 200 mg) IV every 8 to 12 hours

Renal Dosing

CrCl (mL/min) Dose
Oral
>30 875/125 mg p.o. q12h
10-29 500/125 mg p.o. q12h
<10 500/125 mg p.o. q24h
Hemodialysis 500/125 mg p.o. q24h (given after dialysis on dialysis days)
Peritoneal dialysis 250/125 mg p.o. q12h
CRRT Usual dose
Intravenous
>30 1 g IV q8h
10-29 1 g IV followed by 500 mg IV q12h
<10 1 g IV followed by 500 mg IV q24h
Hemodialysis 1 g IV followed by 500 mg IV q24h (given after dialysis on dialysis days)