Quinine: Difference between revisions
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* The main indication is for treatment of [[malaria]] |
* The main indication is for treatment of [[malaria]] |
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* Used off-label as a treatment for nocturnal leg cramps |
* Used off-label as a treatment for nocturnal leg cramps[[CiteRef::hogan2015qu]] |
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== Safety == |
== Safety == |
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Latest revision as of 17:20, 27 September 2024
Background
- The main indication is for treatment of malaria
- Used off-label as a treatment for nocturnal leg cramps1
Safety
Adverse Effects
- Cinchonism: tinnitus, high-tone hearing loss, photophobia and other visual disturbances, dysphoria, headache, nausea, vomiting, sweating, dizziness and postural hypotension
- Hypoglycemia, from pancreatic β cell stimulation
- Hypotension, usually from IV infusion
- Hearing and visual disturbances, including irreversible loss
- Gastrointestinal symptoms
- Cutaneous effects
- Mild QT prolongation (rare unless plasma levels are elevated) and arrhythmias
- Hemolysis (in patients with G6PD deficiency or with hypersensitivity)
References
- ^ David B. Hogan. Quinine: not a safe drug for treating nocturnal leg cramps. Canadian Medical Association Journal. 2015;187(4):237-238. doi:10.1503/cmaj.150044.
