Quinine: Difference between revisions
From IDWiki
(Created page with "== Background == * The main indication is for treatment of malaria * Used off-label (and possibly dangerously and ineffectively) as a treatment for nocturnal leg cramps == Safety == === Adverse Effects === * '''Cinchonism''': tinnitus, high-tone hearing loss, photophobia and other visual disturbances, dysphoria, headache, nausea, vomiting, sweating, dizziness and postural hypotension * Hypoglycemia, from pancreatic β cell stimulation * Hypotension, usually from...") |
mNo edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 2: | Line 2: | ||
* The main indication is for treatment of [[malaria]] |
* The main indication is for treatment of [[malaria]] |
||
| − | * Used off-label |
+ | * Used off-label as a treatment for nocturnal leg cramps[[CiteRef::hogan2015qu]] |
== Safety == |
== Safety == |
||
Latest revision as of 13:20, 27 September 2024
Background
- The main indication is for treatment of malaria
- Used off-label as a treatment for nocturnal leg cramps1
Safety
Adverse Effects
- Cinchonism: tinnitus, high-tone hearing loss, photophobia and other visual disturbances, dysphoria, headache, nausea, vomiting, sweating, dizziness and postural hypotension
- Hypoglycemia, from pancreatic β cell stimulation
- Hypotension, usually from IV infusion
- Hearing and visual disturbances, including irreversible loss
- Gastrointestinal symptoms
- Cutaneous effects
- Mild QT prolongation (rare unless plasma levels are elevated) and arrhythmias
- Hemolysis (in patients with G6PD deficiency or with hypersensitivity)
References
- ^ David B. Hogan. Quinine: not a safe drug for treating nocturnal leg cramps. Canadian Medical Association Journal. 2015;187(4):237-238. doi:10.1503/cmaj.150044.
