Daratumumab: Difference between revisions
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== Background == |
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* IgG1K human monoclonal antibody targetting CD38 |
* IgG1K human monoclonal antibody targetting CD38 |
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* Indications include [[multiple myeloma]] |
* Indications include [[multiple myeloma]] |
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== Adverse Effects == |
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* Adverse effects include [[hypertension]] (10%), edema, fatigue, cytopenias including anemia, liver enzyme abnormalities, infusion reactions (35% with first infusion), cytokine release syndrome, anaphylaxis, electrolyte abnormalities, headache (10%), insomnia, cough, dyspnea, rhinitis |
* Adverse effects include [[hypertension]] (10%), edema, fatigue, cytopenias including anemia, liver enzyme abnormalities, infusion reactions (35% with first infusion), cytokine release syndrome, anaphylaxis, electrolyte abnormalities, headache (10%), insomnia, cough, dyspnea, rhinitis |
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* Risk of infections, including [[CMV]], [[HSV]], and possible [[hepatitis B]] |
* Risk of infections, including [[CMV]], [[HSV]], and possible [[hepatitis B]] |
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== Further Reading == |
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* [https://www.cancercareontario.ca/en/system/files_force/daratumumab.pdf?download=1 Cancer Care Ontario drug monograph] |
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[[Category:Medications]] |
[[Category:Medications]] |
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Latest revision as of 15:03, 9 February 2023
Background
- IgG1K human monoclonal antibody targetting CD38
- Indications include multiple myeloma
Adverse Effects
- Adverse effects include hypertension (10%), edema, fatigue, cytopenias including anemia, liver enzyme abnormalities, infusion reactions (35% with first infusion), cytokine release syndrome, anaphylaxis, electrolyte abnormalities, headache (10%), insomnia, cough, dyspnea, rhinitis
- Risk of infections, including CMV, HSV, and possible hepatitis B
