Cryptococcus (IDSA 2010): Difference between revisions
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[https://doi.org/10.1086/649858 Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update] |
[https://doi.org/10.1086/649858 Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update] |
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= Meningoencephalitis = |
== Meningoencephalitis == |
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== HIV-infected == |
=== HIV-infected === |
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* Induction: AmBd 0.7-1 mg/kg/d IV plus flucytosine 100 mg/kg/d po split QID for at least 2 weeks |
* Induction: AmBd 0.7-1 mg/kg/d IV plus flucytosine 100 mg/kg/d po split QID for at least 2 weeks |
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** If high |
** If high |
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== Organ transplant == |
=== Organ transplant === |
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== Neither HIV infected nor organ transplant == |
=== Neither HIV infected nor organ transplant === |
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= Complications = |
== Complications == |
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= Non-meningeal Cryptococcosis = |
== Non-meningeal Cryptococcosis == |
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= Special Populations = |
== Special Populations == |
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[[Category:IDSA guidelines]] |
[[Category:IDSA guidelines]] |
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Latest revision as of 19:33, 15 August 2019
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update
Meningoencephalitis
HIV-infected
- Induction: AmBd 0.7-1 mg/kg/d IV plus flucytosine 100 mg/kg/d po split QID for at least 2 weeks
- Can use liposomal AmB 3–4 mg/kg/d IV or ABLC 5 mg/kg/d IV
- Can continue for 4-6 weeks if high fungal burden or failure to respond
- Can replace flucytosine with fluconazole 800-1200 mg daily for minimum of 8 weeks if needed
- Consolidation: fluconazole 400 mg daily for at least 8 weeks
- If high
