Baricitinib: Difference between revisions
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==Dosing== |
==Dosing== |
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* 4 mg p.o. daily for 14 days, or until hospital discharge |
* Severe or critical [[COVID-19]]: 4 mg p.o. daily for 14 days, or until hospital discharge |
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===Renal Dosing=== |
===Renal Dosing=== |
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* eGFR 30-60 mL/min: 2 mg p.o. daily |
* eGFR 30-60 mL/min: 2 mg p.o. daily |
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* eGFR 15-30 mL/min: 1 mg p.o. daily |
* eGFR 15-30 mL/min: 2 mg p.o. every other day, or 1 mg p.o. daily |
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* eGFR less than 15 mL/min: not recommended |
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* Dialysis: not recommended |
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== Safety == |
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=== Contraindications === |
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* Contraindications and relative contraindications include hypersensitivity, co-existing infection, immunosuppression, increase liver enzymes |
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=== Adverse Reactions === |
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* Increased risk of infections |
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* Venous thrombosis and thromboembolism |
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[[Category:Medications]] |
[[Category:Medications]] |
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Latest revision as of 14:54, 6 May 2025
Background
- Oral JAK inhibitor
- Indications include COVID-19
Dosing
- Severe or critical COVID-19: 4 mg p.o. daily for 14 days, or until hospital discharge
Renal Dosing
- eGFR 30-60 mL/min: 2 mg p.o. daily
- eGFR 15-30 mL/min: 2 mg p.o. every other day, or 1 mg p.o. daily
- eGFR less than 15 mL/min: not recommended
- Dialysis: not recommended
Safety
Contraindications
- Contraindications and relative contraindications include hypersensitivity, co-existing infection, immunosuppression, increase liver enzymes
Adverse Reactions
- Increased risk of infections
- Venous thrombosis and thromboembolism
