Cefazolin: Difference between revisions
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== Dosing == |
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* Low dose (for UTI or uncomplicated soft tissue infection): 1 g IV |
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* Standard dose: 2 h IV q8h |
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* High dose (for critical illness and IE): 2 g IV q6h |
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=== Renal Dosing === |
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{| class="wikitable" |
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! eGFR (mL/min) |
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! Standard Dose |
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! High Dose |
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|- |
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| >40 |
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| 2 g IV q8h |
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|2 g IV q6h |
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|- |
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| 20-40 |
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| 2 g IV q12h |
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| 2 g IV q12h |
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|- |
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| <20 |
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| 1 g IV q24h |
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| 1 g IV q24h |
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|- |
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|HD |
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|1-2 g IV after each session of hemodialysis, or q24h |
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|- |
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|PD |
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|1-2 g IV q24h |
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|- |
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| CRRT |
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| 2 h IV q12h |
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| 2 h IV q12h |
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|} |
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[[Category:Cephalosporins]] |
[[Category:Cephalosporins]] |
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Latest revision as of 16:56, 18 December 2025
Background
Clinical Breakpoints
| Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||
|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||
| Enterobacteriaceae (systemic) | ≤2 | 4 | ≥8 | ||||
| Enterobacteriaceae (urinary) | ≤16 | ≥32 | |||||
Dosing
- Low dose (for UTI or uncomplicated soft tissue infection): 1 g IV
- Standard dose: 2 h IV q8h
- High dose (for critical illness and IE): 2 g IV q6h
Renal Dosing
| eGFR (mL/min) | Standard Dose | High Dose |
|---|---|---|
| >40 | 2 g IV q8h | 2 g IV q6h |
| 20-40 | 2 g IV q12h | 2 g IV q12h |
| <20 | 1 g IV q24h | 1 g IV q24h |
| HD | 1-2 g IV after each session of hemodialysis, or q24h | |
| PD | 1-2 g IV q24h | |
| CRRT | 2 h IV q12h | 2 h IV q12h |
