Primary aldosteronism: Difference between revisions
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(Created page with " == Differential Diagnosis == * Bilateral adrenal hyperplasia (60%) * Adrenal adenoma, which causes [Conn syndrome] * Adrenal carcinoma (rare) * Familial hyperaldosteronism...") |
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== Clinical Manifestations == |
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* Usually asymptomatic except for hypertension and hypokalemia |
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* Can have muscle cramps |
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* Family history |
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* Resistant hypertension |
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* Adrenal incidentaloma |
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* Early onset hypertension |
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* High normal sodium |
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* Metabolic alkalosis |
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== Differential Diagnosis == |
== Differential Diagnosis == |
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* Bilateral adrenal hyperplasia (60%) |
* Bilateral [[adrenal hyperplasia]] (60%) |
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* Adrenal adenoma, which causes [Conn syndrome] |
* [[Adrenal adenoma]], which causes [[Conn syndrome]] |
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* Adrenal carcinoma (rare) |
* [[Adrenal carcinoma]] (rare) |
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* Familial hyperaldosteronism |
* [[Familial hyperaldosteronism]] |
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== Diagnosis == |
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* Screening with plasma aldosterone/plasma renin ratio |
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** Done preferably in morning sample |
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** Taken in a sitting position after at least 15 minutes of rest |
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** Avoid aldosterone antagonists, ARBs, β-blockers |
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* Diagnosed with: |
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** Oral salt load |
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** Saline suppression |
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** Captopril |
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== Management == |
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* Surgery if unilateral |
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* [[Spironolactone]] if bilateral |
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[[Category:Endocrinology]] |
[[Category:Endocrinology]] |
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Latest revision as of 17:50, 15 October 2021
Clinical Manifestations
- Usually asymptomatic except for hypertension and hypokalemia
- Can have muscle cramps
- Family history
- Resistant hypertension
- Adrenal incidentaloma
- Early onset hypertension
- High normal sodium
- Metabolic alkalosis
Differential Diagnosis
- Bilateral adrenal hyperplasia (60%)
- Adrenal adenoma, which causes Conn syndrome
- Adrenal carcinoma (rare)
- Familial hyperaldosteronism
Diagnosis
- Screening with plasma aldosterone/plasma renin ratio
- Done preferably in morning sample
- Taken in a sitting position after at least 15 minutes of rest
- Avoid aldosterone antagonists, ARBs, β-blockers
- Diagnosed with:
- Oral salt load
- Saline suppression
- Captopril
Management
- Surgery if unilateral
- Spironolactone if bilateral
