Bacterial meningitis (IDSA 2004): Difference between revisions

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= Table 4: Empiric Treatment =
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==Table 4: Empiric Treatment==
   
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{| class="wikitable"
{|
 
! Population
+
!Population
! Common pathogens
+
!Common pathogens
! Antimicrobial therapy
+
!Antimicrobial therapy
 
|-
 
|-
| Age
+
! colspan="3" |Age
|
 
|
 
 
|-
 
|-
| <1 month
+
|<1 month
| GBS, E.coli, Listeria, Klebsiella
+
|[[Group B streptococcus]], [[Escherichia coli]], [[Listeria]], [[Klebsiella]]
| amp + cefotax, or<br/>amp + AG
+
|amp + cefotax, or<br />amp + AG
 
|-
 
|-
| 1-23 months
+
|1-23 months
  +
|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Group B streptococcus]], [[Haemophilus influenzae]], [[Escherichia coli]]
| S.pneumo, N.mening, GBS, H.flu, E.coli
 
| vanco + 3G ceph
+
|vanco + 3G ceph
 
|-
 
|-
| 2-50 years
+
|2-50 years
  +
|[[Neisseria meningitidis]], [[Streptococcus pneumoniae]]
| N.mening, S.pneumo
 
| vanco + 3G ceph
+
|vanco + 3G ceph
 
|-
 
|-
| &gt;50 years
+
|&gt;50 years
  +
|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Listeria]], [[Gram-negative bacilli]]
| S.pneumo, N.mining, Listeria, GNBs
 
| vanco + 3G ceph + amp
+
|vanco + 3G ceph + amp
 
|-
 
|-
| Head trauma
+
! colspan="3" |Head trauma
|
 
|
 
 
|-
 
|-
| Basilar skull fracture
+
|Basilar skull fracture
  +
|[[Streptococcus pneumoniae]], [[Haemophilus influenzae]], [[GAS]]
| S.pneumo, H.flu, GAS
 
| vanco + 3G ceph
+
|vanco + 3G ceph
 
|-
 
|-
| Penetrating trauma
+
|Penetrating trauma
  +
|[[Staphylococcus aureus]], [[coagulase-negative staphylococci]], [[Gram-negative bacilli]]
| Staph.aureus, CoNS, GNBs
 
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
+
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
 
|-
 
|-
| Post-neurosurgery
+
|Post-neurosurgery
  +
|[[Gram-negative bacilli]], [[Staphylococcus aureus]], [[coagulase-negative staphylococci]]
| GNBs, Staph.aureus, CoNS
 
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
+
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
 
|-
 
|-
| CSF shunt
+
|CSF shunt
  +
|[[Coagulase-negative staphylococci]], [[Staphylococcus aureus]], [[Gram-negative bacilli]], [[Cutibacterium acnes]]
| CoNS, Staph,aureus, GNBs, P.acnes
 
| vanco + cefep, or<br/>vanco + ceftaz, or<br/>vanco + mero
+
|vanco + cefep, or<br />vanco + ceftaz, or<br />vanco + mero
 
|}
 
|}
   

Latest revision as of 15:51, 2 August 2020

Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004 Nov 1;39(9):1267-84. Epub 2004 Oct 6. doi: 10.1086/425368


Table 4: Empiric Treatment

Population Common pathogens Antimicrobial therapy
Age
<1 month Group B streptococcus, Escherichia coli, Listeria, Klebsiella amp + cefotax, or
amp + AG
1-23 months Streptococcus pneumoniae, Neisseria meningitidis, Group B streptococcus, Haemophilus influenzae, Escherichia coli vanco + 3G ceph
2-50 years Neisseria meningitidis, Streptococcus pneumoniae vanco + 3G ceph
>50 years Streptococcus pneumoniae, Neisseria meningitidis, Listeria, Gram-negative bacilli vanco + 3G ceph + amp
Head trauma
Basilar skull fracture Streptococcus pneumoniae, Haemophilus influenzae, GAS vanco + 3G ceph
Penetrating trauma Staphylococcus aureus, coagulase-negative staphylococci, Gram-negative bacilli vanco + cefep, or
vanco + ceftaz, or
vanco + mero
Post-neurosurgery Gram-negative bacilli, Staphylococcus aureus, coagulase-negative staphylococci vanco + cefep, or
vanco + ceftaz, or
vanco + mero
CSF shunt Coagulase-negative staphylococci, Staphylococcus aureus, Gram-negative bacilli, Cutibacterium acnes vanco + cefep, or
vanco + ceftaz, or
vanco + mero