Metronidazole: Difference between revisions
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= Metronidazole = |
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* [[Adverse drug reaction::Disulfiram-like reaction]] with alcohol ingestion |
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=== Peripheral neuropathy === |
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=== [[Adverse drug reaction::Peripheral Neuropathy]] === |
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* Starts after 4 weeks or 42 grams |
* Starts after 4 weeks or 42 grams |
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* Free radicals causing nerve damage, and metronidazole causes degeneration |
* Free radicals causing nerve damage, and metronidazole causes degeneration |
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* Usually resolves in 2 weeks (but may take up to 24 weeks) |
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* Usually reversible but takes time |
* Usually reversible (about 75%) but takes time |
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=== Neurotoxicity === |
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* Can cause seizures and encephalopathy |
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* MRI may show bilateral symmetric T2 hyperintense lesions, which resolve after cessation of metronidazole |
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[[Category:Antibiotics]] |
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Latest revision as of 16:21, 20 September 2022
Adverse Drug Reactions
- Disulfiram-like reaction with alcohol ingestion
Peripheral Neuropathy
- Starts after 4 weeks or 42 grams
- Free radicals causing nerve damage, and metronidazole causes degeneration
- Usually resolves in 2 weeks (but may take up to 24 weeks)
- Usually reversible (about 75%) but takes time
Neurotoxicity
- Can cause seizures and encephalopathy
- MRI may show bilateral symmetric T2 hyperintense lesions, which resolve after cessation of metronidazole
