Adenovirus: Difference between revisions
From IDWiki
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===Epidemiology=== |
===Epidemiology=== |
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*Transmitted by droplets or aerosol |
*Transmitted by droplets or aerosol, or fecal-oral or via vomitus |
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==Clinical Manifestations== |
==Clinical Manifestations== |
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**Disseminated disease |
**Disseminated disease |
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**[[Hemorrhagic cystitis]] in hematopoietic stem cell transplant patients and children |
**[[Hemorrhagic cystitis]] in hematopoietic stem cell transplant patients and children |
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=== Gastroenteritis === |
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* Some serotypes are uncommon causes of [[Causes::viral gastroenteritis]] |
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* Incubation period is 10 days |
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* Usually no vomiting, but otherwise typical course of [[gastroenteritis]] |
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* Lasts up to 2 weeks with serotypes 40 and 41 |
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==Diagnosis== |
==Diagnosis== |
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Latest revision as of 23:59, 22 August 2020
Background
Microbiology
- Non-enveloped double-stranded DNA virus
- Seven species with multiple serotypes
Epidemiology
- Transmitted by droplets or aerosol, or fecal-oral or via vomitus
Clinical Manifestations
- Common cause of upper respiratory infections (colds) in immunocompetent people
- Can also cause pharyngitis, pharyngoconjunctival fever, epidemic keratoconjunctivitis, acute hemorrhagic conjunctivitis, hepatitis, urethritis or genital ulcers (sexually-transmitted)
- In cellular immunodeficiency or neonates, can cause severe disease
- Disseminated disease
- Hemorrhagic cystitis in hematopoietic stem cell transplant patients and children
Gastroenteritis
- Some serotypes are uncommon causes of viral gastroenteritis
- Incubation period is 10 days
- Usually no vomiting, but otherwise typical course of gastroenteritis
- Lasts up to 2 weeks with serotypes 40 and 41
Diagnosis
- Typically by PCR
- May see smudge cells on histology (but not specific)
Management
- Usually treated supportively
- Only current effective treatment is cidofovir, indicated in severe or life-threatening disease
