Oseltamivir: Difference between revisions
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===Mechanism of Action=== |
===Mechanism of Action=== |
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*Inhibits viral neuraminidase |
*Inhibits viral neuraminidase, which is required for virion release after budding |
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==Dose== |
==Dose== |
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===Adults=== |
===Adults=== |
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*Influenza (treatment): 75 mg PO bid |
*Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset |
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*Influenza (prophylaxis): 75 mg PO daily |
*Influenza (prophylaxis): 75 mg PO daily |
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====Renal Dosing==== |
====Renal Dosing==== |
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{| class |
{| class="wikitable" |
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!Indication |
!Indication |
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!CrCl >60 |
!CrCl >60 |
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!CrCl >10 to 30 mL/min |
!CrCl >10 to 30 mL/min |
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!IHD |
!IHD |
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!CAPD |
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!CRRT |
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|- |
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|Influenza (treatment) |
|Influenza (treatment) |
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|30 mg PO daily |
|30 mg PO daily |
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|30 (low-flux) to 75 (high-flux) mg PO after dialysis |
|30 (low-flux) to 75 (high-flux) mg PO after dialysis |
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|30 mg PO once |
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|30 mg once daily |
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|- |
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|Influenza (prophylaxis) |
|Influenza (prophylaxis) |
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|30 mg PO every other day |
|30 mg PO every other day |
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|30 mg PO after every other dialysis |
|30 mg PO after every other dialysis |
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|30 mg PO weekly |
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|Unclear |
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|} |
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==== Hepatic Dosing ==== |
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* No dose adjustment needed |
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===Pediatric=== |
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*Influenza (treatment): |
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**Infants ≤8 months: 3 mg/kg/dose PO bid |
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**Infants ≥9 months: 3.5 mg/kg/dose PO bid |
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**Children ≤15 kg: 30 mg PO bid |
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**Children >15 to 23 kg: 45 mg PO bid |
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**Children >23 to 40 kg: 60 mg PO bid |
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**Children & adolescents >40 kg: 75 mg PO bid (adult dose) |
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**Duration 5 days, started within 48 hours of illness onset |
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*Influenza (prophylaxis): |
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**Same doses as above, used once daily instead of bid |
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[[Category:Antivirals]] |
[[Category:Antivirals]] |
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Latest revision as of 14:52, 31 July 2020
Background
Mechanism of Action
- Inhibits viral neuraminidase, which is required for virion release after budding
Dose
Adults
- Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
- Influenza (prophylaxis): 75 mg PO daily
Renal Dosing
| Indication | CrCl >60 | CrCl >30 to 60 mL/min | CrCl >10 to 30 mL/min | IHD | CAPD | CRRT |
|---|---|---|---|---|---|---|
| Influenza (treatment) | Usual dose | 30 mg PO bid | 30 mg PO daily | 30 (low-flux) to 75 (high-flux) mg PO after dialysis | 30 mg PO once | 30 mg once daily |
| Influenza (prophylaxis) | Usual dose | 30 mg PO daily | 30 mg PO every other day | 30 mg PO after every other dialysis | 30 mg PO weekly | Unclear |
Hepatic Dosing
- No dose adjustment needed
Pediatric
- Influenza (treatment):
- Infants ≤8 months: 3 mg/kg/dose PO bid
- Infants ≥9 months: 3.5 mg/kg/dose PO bid
- Children ≤15 kg: 30 mg PO bid
- Children >15 to 23 kg: 45 mg PO bid
- Children >23 to 40 kg: 60 mg PO bid
- Children & adolescents >40 kg: 75 mg PO bid (adult dose)
- Duration 5 days, started within 48 hours of illness onset
- Influenza (prophylaxis):
- Same doses as above, used once daily instead of bid
