Opioids: Difference between revisions
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== |
==Background== |
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* |
*Class of analgesic medications that act primarily on the μ-opioid receptor |
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== |
==Morphine Milligram Equivalent Dose== |
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{| class="wikitable" |
{| class="wikitable" |
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!Drug |
!Drug |
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!MME per mg IV/SC |
!MME per mg IV/SC |
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|[[ |
|[[Meperidine]] |
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|0.1 |
|0.1 |
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|— |
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|[[Codeine]] |
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|0.15 |
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|— |
|— |
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|[[Oxycodone]] |
|[[Oxycodone]] |
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|1.5 |
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|— |
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|[[Methadone]] |
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|3 |
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|— |
|— |
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===Fentanyl=== |
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| ⚫ | |||
{| class="wikitable" |
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!Fentanyl mcg/h |
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!MME |
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|- |
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|25 |
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|60-134 |
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|37 |
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|135-179 |
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|50 |
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|180-224 |
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|- |
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|62 |
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|225-269 |
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|75 |
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|270-314 |
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|- |
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|87 |
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|315-359 |
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|100 |
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|360-404 |
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| ⚫ | |||
<br /> |
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== Safety == |
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=== Adverse Events === |
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{| class="wikitable" |
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! |
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!Common |
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!Occasional |
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!Rare |
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|Gastrointestinal |
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|nausea, vomiting, constipation |
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|delayed gastric emptying |
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|biliary coli |
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|Neurological |
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|sedation, drowsiness, cognitive dysfunction |
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|hallucinations, mood disturbance, anxiety, myoclonus |
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|delirium, seizure, addiction |
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|Respiratory |
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|inhibition of cough reflex |
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|dry mouth, bronchospasm |
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|respiratory depression, non-cardiac pulmonary edema |
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|Others |
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|miosis |
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|pruritus, muscle rigidity |
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|hyperalgesia, allodynia, tolerance, physical dependence |
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[[Category:Addiction medicine]] |
[[Category:Addiction medicine]] |
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[[Category:Anaesthesia]] |
[[Category:Anaesthesia]] |
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Latest revision as of 15:52, 7 May 2021
Background
- Class of analgesic medications that act primarily on the μ-opioid receptor
Morphine Milligram Equivalent Dose
| Drug | MME per mg PO | MME per mg IV/SC |
|---|---|---|
| Meperidine | 0.1 | — |
| Codeine | 0.15 | — |
| Morphine | 1 | 2 |
| Oxycodone | 1.5 | — |
| Methadone | 3 | — |
| Hydromorphone | 5 | 10 |
| Fentanyl | 200 MME per 50 mcg/h transdermal | |
Fentanyl
| Fentanyl mcg/h | MME |
|---|---|
| 25 | 60-134 |
| 37 | 135-179 |
| 50 | 180-224 |
| 62 | 225-269 |
| 75 | 270-314 |
| 87 | 315-359 |
| 100 | 360-404 |
- IV is essentially twice as strong as PO
Safety
Adverse Events
| Common | Occasional | Rare | |
|---|---|---|---|
| Gastrointestinal | nausea, vomiting, constipation | delayed gastric emptying | biliary coli |
| Neurological | sedation, drowsiness, cognitive dysfunction | hallucinations, mood disturbance, anxiety, myoclonus | delirium, seizure, addiction |
| Respiratory | inhibition of cough reflex | dry mouth, bronchospasm | respiratory depression, non-cardiac pulmonary edema |
| Others | miosis | pruritus, muscle rigidity | hyperalgesia, allodynia, tolerance, physical dependence |
