Immune reconstitution inflammatory syndrome: Difference between revisions
From IDWiki
(Created page with "== Background == * Two main forms: ** '''Unmasking''': an underlying, previously undiagnosed infection becomes clinically apparent following immune reconstitution ** '''Parad...") |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== |
==Background== |
||
* |
*Two main forms: |
||
** |
**'''Unmasking''': an underlying, previously undiagnosed infection becomes clinically apparent following immune reconstitution |
||
** |
**'''Paradoxical''': a diagnosed and treated infection worsens following immune reconstitution |
||
=== |
=== Microbiology === |
||
* Mycobacteria |
|||
| ⚫ | |||
** [[Mycobacterium tuberculosis]] |
|||
| ⚫ | |||
** [[Mycobacterium avium complex]] |
|||
* Fungi |
|||
** [[Cryptococcus neoformans]] |
|||
* Viruses |
|||
** [[Cytomegalovirus]] |
|||
** [[Kaposi sarcoma-associated herpesvirus]] |
|||
===Risk Factors=== |
|||
| ⚫ | |||
| ⚫ | |||
== Clinical Manifestations == |
|||
* Varies by underlying infection |
|||
* Onset usually a month following starting antiretrovirals, but can be up to a year |
|||
** Mostly within 4 to 8 weeks of starting or changing ART, but with a range from 3 days to several months (or in case reports up to years) |
|||
== Further Reading == |
|||
* Central Nervous System Immune Reconstitution Inflammatory Syndrome. ''Curr Infect Dis Rep''. 2013;15(6). doi: [[/doi.org/10.1007/s11908-013-0378-5|10.1007/s11908-013-0378-5]] |
|||
** Provides an overview of CNS-related IRIS syndromes. |
|||
[[Category:HIV]] |
[[Category:HIV]] |
||
Latest revision as of 16:24, 15 October 2024
Background
- Two main forms:
- Unmasking: an underlying, previously undiagnosed infection becomes clinically apparent following immune reconstitution
- Paradoxical: a diagnosed and treated infection worsens following immune reconstitution
Microbiology
- Mycobacteria
- Fungi
- Viruses
Risk Factors
- High viral load
- Low CD4 count
Clinical Manifestations
- Varies by underlying infection
- Onset usually a month following starting antiretrovirals, but can be up to a year
- Mostly within 4 to 8 weeks of starting or changing ART, but with a range from 3 days to several months (or in case reports up to years)
Further Reading
- Central Nervous System Immune Reconstitution Inflammatory Syndrome. Curr Infect Dis Rep. 2013;15(6). doi: 10.1007/s11908-013-0378-5
- Provides an overview of CNS-related IRIS syndromes.
