Hepatic encephalopathy: Difference between revisions
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== Grading == |
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* '''Grade 0:''' no encephalopathy |
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** Normal consciousness, personality, neurological examination, and electroencephalogram |
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* '''Grade 1:''' changes in behaviour with minimal change in level of consciousness |
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** Restless, sleep disturbed, irritable/agitated, termor, impaired handwriting, 5 cps waves on EEG |
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* '''Grade 2:''' gross disorientation, drowsiness, possibly asterixis, inappropriate behaviour |
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** Lethargic, time-disoriented, inappropriate, asterixis, ataxia, slow triphasic waves on EEG |
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* '''Grade 3:''' marked confusion, incoherent speech, sleeping most of the time but arousable to vocal stimulus |
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** Somnolent, stuporous, place-disoriented, hyperactive reflexes, rigidity, slower waves on EEG |
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* '''Grade 4:''' comatose, unresponsive to pain, decorticate or decerebrate posturing |
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** Unrousable coma, no personality/behvaiour, decerebrate, slow 2-3 cps delta activity on EEG |
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== Investigations == |
== Investigations == |
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Latest revision as of 18:01, 9 March 2022
Grading
- Grade 0: no encephalopathy
- Normal consciousness, personality, neurological examination, and electroencephalogram
- Grade 1: changes in behaviour with minimal change in level of consciousness
- Restless, sleep disturbed, irritable/agitated, termor, impaired handwriting, 5 cps waves on EEG
- Grade 2: gross disorientation, drowsiness, possibly asterixis, inappropriate behaviour
- Lethargic, time-disoriented, inappropriate, asterixis, ataxia, slow triphasic waves on EEG
- Grade 3: marked confusion, incoherent speech, sleeping most of the time but arousable to vocal stimulus
- Somnolent, stuporous, place-disoriented, hyperactive reflexes, rigidity, slower waves on EEG
- Grade 4: comatose, unresponsive to pain, decorticate or decerebrate posturing
- Unrousable coma, no personality/behvaiour, decerebrate, slow 2-3 cps delta activity on EEG
Investigations
- In general, discourage measuring serum ammonia
Management
Acute
- Lactulose
Chronic prophylaxis
- Lactulose
- Add-on: rifaximin
- Reassess adherence
- Assess for medications contributing to encephalopathy