Crystalloid fluids: Difference between revisions
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! Fluid |
! Fluid |
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! Na |
! Na |
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* Isotonic |
* Isotonic |
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* Causes a metabolic hyperchloremic acidosis, decreasing a normal pH to 7.28 after 2L! |
* Causes a metabolic hyperchloremic acidosis, decreasing a normal pH to 7.28 after 2L! |
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* Cheapest and most widely available crystalloid |
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== Ringer's lactate == |
== Ringer's lactate == |
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* Contains 28 mmol/L of lactate |
* Contains 28 mmol/L of lactate |
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* Has no effect on acid-base status |
* Has no effect on acid-base status |
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* Lower risk of [[AKI]] compared to normal saline when used for resuscitation |
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== Plastmalyte == |
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* SPLIT cluster RCT saw no difference in [[AKI]] and ICU mortality compared to normal saline, though most patients were not particularly ill |
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== D5W == |
== D5W == |
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Latest revision as of 21:23, 19 May 2021
| Fluid | Na | Cl | K | Ca | Mg | pH | Osm |
|---|---|---|---|---|---|---|---|
| Plasma | 140 | 103 | 4 | 4 | 2 | 7.4 | 290 |
| 0.9% saline | 154 | 154 | 5.7 | 308 | |||
| 0.45% saline | 76 | 76 | ?? | 154 | |||
| Ringer's lactate | 130 | 109 | 4 | 3 | 6.5 | 273 |
Normal saline
- Isotonic
- Causes a metabolic hyperchloremic acidosis, decreasing a normal pH to 7.28 after 2L!
- Cheapest and most widely available crystalloid
Ringer's lactate
- Contains 28 mmol/L of lactate
- Has no effect on acid-base status
- Lower risk of AKI compared to normal saline when used for resuscitation
Plastmalyte
- SPLIT cluster RCT saw no difference in AKI and ICU mortality compared to normal saline, though most patients were not particularly ill
D5W
- Provides 170kcal/L of dextrose (3L/d can protect against protein breakdown)
- 65% moves intracellularly
