Dapsone: Difference between revisions
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==Background== |
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= Dapsone = |
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*Diamino-diphenyl sulfone |
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===Indications=== |
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*Second-line [[Pneumocystis jirovecii]] prophylaxis (CD4 <200) |
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*Along with [[rifampicin]] and [[clofazimine]] as multidrug therapy (MDT) for the treatment of ''[[Mycobacterium leprae]]'' |
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==Dosing== |
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*'''[[Dermatitis herpetiformis]]''' |
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**Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose |
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**Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days |
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**After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks |
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*'''[[Pneumocystis]] prophylaxis (primary or secondary)''' |
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**100 mg PO once daily or in 2 divided doses as monotherapy |
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**Continue until CD4 count >200 cells/mm3 for >3 months |
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*'''[[Pneumocystis]] treatment:''' 100 mg PO once daily in combination with [[trimethoprim]] for 21 days |
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==Safety== |
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*Check CBC, liver, and G6PD deficiency before starting |
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[[Category:Antibiotics]] |
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Latest revision as of 13:15, 3 March 2021
Background
- Diamino-diphenyl sulfone
Indications
- Second-line Pneumocystis jirovecii prophylaxis (CD4 <200)
- Along with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae
Dosing
- Dermatitis herpetiformis
- Start at 50 mg PO daily, increase to 300 mg daily in 25 mg increments every 1 to 2 weeks, up to 2 mg/kg/dose
- Pruritus usually improves within 72 hours, and the skin manifestations typically resolve within days
- After 2-3 months of gluten-free diet, start tapering by 25 mg every four to six weeks
- Pneumocystis prophylaxis (primary or secondary)
- 100 mg PO once daily or in 2 divided doses as monotherapy
- Continue until CD4 count >200 cells/mm3 for >3 months
- Pneumocystis treatment: 100 mg PO once daily in combination with trimethoprim for 21 days
Safety
- Check CBC, liver, and G6PD deficiency before starting
