Alternaria: Difference between revisions
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Alternaria
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== Background == |
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* A [[Dematiaceous molds|dematiaceous mold]] that mainly causes cutaneous infections in immunocompromised patients |
* A [[Dematiaceous molds|dematiaceous mold]] that mainly causes cutaneous infections in immunocompromised patients |
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== Clinical |
== Clinical Manifestations == |
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* Predominantly causes cutaneous or subcutaneous lesions in immunocompromised patients |
* Predominantly causes cutaneous or subcutaneous lesions in immunocompromised patients |
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* Lesions are often on the dorsal part of the hands and feet, elbows, knees and pretibial area |
* Lesions are often on the dorsal part of the hands and feet, elbows, knees and pretibial area |
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== Management == |
== Management == |
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* Wide excisional surgery, treatment with [[Is treated by::itraconazole]], [[Is treated by::voriconazole]], [[Is treated by::posaconazole]] and [[Is treated by::amphotericin B]] |
* Wide excisional surgery, treatment with [[Is treated by::itraconazole]], [[Is treated by::voriconazole]], [[Is treated by::posaconazole]] and [[Is treated by::amphotericin B]] |
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* High |
* High MICs to [[echinocandins]], but may possibly be used in combination |
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{{DISPLAYTITLE:''Alternaria'' |
{{DISPLAYTITLE:''Alternaria''}} |
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[[Category:Dematiaceous molds]] |
[[Category:Dematiaceous molds]] |
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Latest revision as of 20:52, 27 January 2022
Background
- A dematiaceous mold that mainly causes cutaneous infections in immunocompromised patients
Clinical Manifestations
- Predominantly causes cutaneous or subcutaneous lesions in immunocompromised patients
- Lesions are often on the dorsal part of the hands and feet, elbows, knees and pretibial area
Diagnosis
- Culture
- Colony
- Grows relatively rapidly (within 7 days) at 30ΒΊC
- Grey to brown colonies with black reverse
- Microscopy
- Yellow-brownish hyphae with or without budding cells
- Muriform macroconidia
- Colony
- Ultimately require culture/microcroscopy +/- DNA targets to make the identification
Management
- Wide excisional surgery, treatment with itraconazole, voriconazole, posaconazole and amphotericin B
- High MICs to echinocandins, but may possibly be used in combination
