Pyrimethamine: Difference between revisions
From IDWiki
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 2: | Line 2: | ||
* Indications include [[Is treatment for::toxoplasmosis]] and [[Is treatment for::malaria]] |
* Indications include [[Is treatment for::toxoplasmosis]] and [[Is treatment for::malaria]] |
||
* Major adverse effects is bone marrow suppression, so need to monitor CBC |
* Major adverse effects is bone marrow suppression, so need to monitor CBC |
||
** Pancytopenia, which is reversible with leucovorin |
** [[Adverse drug reaction::Pancytopenia]], which is reversible with leucovorin |
||
** GI intolerance |
** [[Adverse drug reaction::GI intolerance]] |
||
** Other: rash, hepatitis, headache, dizziness, insomnia |
** Other: [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::headache]], [[Adverse drug reaction::dizziness]], [[Adverse drug reaction::insomnia]] |
||
* Monitoring |
* Monitoring |
||
** CBC q2d initially, then decreasing frequency |
** CBC q2d initially, then decreasing frequency |
||
[[Category:Antibiotics]] |
|||
Latest revision as of 19:10, 20 August 2020
- Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid
- Indications include toxoplasmosis and malaria
- Major adverse effects is bone marrow suppression, so need to monitor CBC
- Pancytopenia, which is reversible with leucovorin
- GI intolerance
- Other: rash, hepatitis, headache, dizziness, insomnia
- Monitoring
- CBC q2d initially, then decreasing frequency
