Fever in a hospitalized patient: Difference between revisions

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==Background==
= Fever in the hospitalized patient =


== Definition ==
===Definition===


* Core temperature >38.3ºC
*Core temperature >38.3ºC


== Pathophysiology ==
===Pathophysiology===


* Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds
*Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds
** Either direct action or cytokine production that stimulates the organum vasculosum of the lamina terminalis (OVLT) in the hypothalamus
**Either direct action or cytokine production that stimulates the organum vasculosum of the lamina terminalis (OVLT) in the hypothalamus
* Neurogenic
*[[Neurogenic fever]]
* Decoupling of oxidative phosphorylation, as in drug-induced
*Decoupling of oxidative phosphorylation, as in [[drug-induced fever]]


== Differential Diagnosis ==
==Differential Diagnosis==


* Infectious
*Infectious
**[[Sinusitis]]
* Non-infectious
*Non-infectious
** Inflammatory diseases
**Inflammatory diseases
** Drug-induced, including ß-lactam antibiotics, sulphonamides, antipsychotics, propofol
**Drug-induced, including ß-lactam antibiotics, sulphonamides, antipsychotics, propofol
** Traumatic brain injury or ischemic brain injury
**Traumatic brain injury or ischemic brain injury
** Endocrine fever
**Endocrine fever


[[Category:Hospital-acquired infections]]
![Causes of drug-induced hyperthermia](Drug-induced hyperthermia.png)
[[Category:Fever syndromes]]

Latest revision as of 02:40, 23 November 2023

Background

Definition

  • Core temperature >38.3ºC

Pathophysiology

  • Pyrogenic fever is caused by endogenous (IL-1, IL-6, TNF-alpha) or exogenous (from a microbe) pyrogen compounds
    • Either direct action or cytokine production that stimulates the organum vasculosum of the lamina terminalis (OVLT) in the hypothalamus
  • Neurogenic fever
  • Decoupling of oxidative phosphorylation, as in drug-induced fever

Differential Diagnosis

  • Infectious
  • Non-infectious
    • Inflammatory diseases
    • Drug-induced, including ß-lactam antibiotics, sulphonamides, antipsychotics, propofol
    • Traumatic brain injury or ischemic brain injury
    • Endocrine fever