Trypanosoma: Difference between revisions
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Trypanosoma
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== |
==Background== |
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===Microbiology=== |
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* Flagellated vector-borne protozoan parasite of mammals in the genus ''Trypanosoma'' |
* Flagellated vector-borne protozoan parasite of mammals in the genus ''Trypanosoma'' |
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* Generally have three morphological states: epimastigote, amastigote, and trypomastigote |
* Generally have three morphological states: epimastigote, amastigote, and trypomastigote |
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** ''T. cruzi'' has an intracellular amastigote while ''T. brucei'' do not, but rather multiply as trypomastigotes in the bloodstream |
** ''[[T. cruzi]]'' has an intracellular amastigote while ''[[T. brucei]]'' do not, but rather multiply as trypomastigotes in the bloodstream |
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** Amastigotes are commonly intracellular, and are small with a very short flagellum |
** Amastigotes are commonly intracellular, and are small with a very short flagellum |
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** Epimastigotes have a flagellum that runs along and connects as an undulating membrane, with the kinetoplast anterior to the nucleus |
** Epimastigotes have a flagellum that runs along and connects as an undulating membrane, with the kinetoplast anterior to the nucleus |
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** Trypomastigotes have a similar flagellum as epimastigotes, but with the kinetoplast posterior to the nucleus |
** Trypomastigotes have a similar flagellum as epimastigotes, but with the kinetoplast posterior to the nucleus |
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[[File:800px-TrypanosomatidMorphologies_PlainSVG.svg.png|Stages of trypanosomes]] |
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* Two major groups |
* Two major groups |
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** ''Stercoraria'', which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut |
** ''Stercoraria'', which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut |
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*** Transferred via contaminated feces |
*** Transferred via contaminated feces |
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*** e.g. '' |
*** e.g. ''[[Trypanosoma cruzi]]'' |
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** ''Salivaria'', which multiply continuously in the mammal as trypomastigotes, and develop in the vector in the salivary glands |
** ''Salivaria'', which multiply continuously in the mammal as trypomastigotes, and develop in the vector in the salivary glands |
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*** Transferred via saliva |
*** Transferred via saliva |
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*** e.g. '' |
*** e.g. ''[[Trypanosoma brucei]]'' |
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* Three species infect humans |
* Three species infect humans |
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** '' |
** ''[[Trypanosoma cruzi]]'', which causes Chagas disease |
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** '' |
** ''[[Trypanosoma brucei gambiense]]'' and ''[[Trypanosoma brucei rhodesiense]]'', which cause African sleeping sickness |
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** Something else? |
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{{DISPLAYTITLE:''Trypanosoma'' |
{{DISPLAYTITLE:''Trypanosoma''}} |
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[[Category: |
[[Category:Protozoa]] |
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Latest revision as of 16:54, 25 January 2022
Background
Microbiology
- Flagellated vector-borne protozoan parasite of mammals in the genus Trypanosoma
- Generally have three morphological states: epimastigote, amastigote, and trypomastigote
- T. cruzi has an intracellular amastigote while T. brucei do not, but rather multiply as trypomastigotes in the bloodstream
- Amastigotes are commonly intracellular, and are small with a very short flagellum
- Epimastigotes have a flagellum that runs along and connects as an undulating membrane, with the kinetoplast anterior to the nucleus
- Trypomastigotes have a similar flagellum as epimastigotes, but with the kinetoplast posterior to the nucleus
- Two major groups
- Stercoraria, which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut
- Transferred via contaminated feces
- e.g. Trypanosoma cruzi
- Salivaria, which multiply continuously in the mammal as trypomastigotes, and develop in the vector in the salivary glands
- Transferred via saliva
- e.g. Trypanosoma brucei
- Stercoraria, which multiply discontinuously in the mammal as amastigotes, and develop in the vector in the hindgut
- Three species infect humans
- Trypanosoma cruzi, which causes Chagas disease
- Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, which cause African sleeping sickness
