John Cunningham virus: Difference between revisions

Latest revision as of 20:23, 14 August 2020

Classic progressive multifocal leukoencephalopathy (PML)
- Subacute onset of focal central neurological lesions
- Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
PML-IRIS
- Focal central neurological lesions following immune recovery
- Contrast enhancing lesions with or without mass effect on MRI
JCV granule cell neuropathy
- Chronic cerebellar dysfunction
- Cerebellar atrophy on MRI
JCV encephalitis
- Subacute onset of encephalopathy
- Cortical lesions on MRI
JCV meningitis
- Chronic headaches
- Ventriculomegaly on MRI

MRI head: white matter changes
CSF: fairly nonspecific, with mild pleocytosis, slightly elevated protein, and normal glucose
- PCR of CSF has sensitivity 58% with ART or 72-92% without, and specificity 92-100%

@@ Line 1: / Line 1: @@
+*CNS infection with JC virus, usually in the context of HIV infection
-= Progressive multifocal leukoencephalopathy (PML) =
-== Etiology ==
+==Background==
+===Epidemiology===
+*HIV patients
-* CNS infection with JC virus, usually in the context of HIV infection
+==Clinical Manifestations==
-== Epidemiology ==
+*'''Classic progressive multifocal leukoencephalopathy (PML)'''
-* HIV patients
+**Subacute onset of focal central neurological lesions
+**Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
+*'''PML-IRIS'''
+**Focal central neurological lesions following immune recovery
+**Contrast enhancing lesions with or without mass effect on MRI
+*'''JCV granule cell neuropathy'''
+**Chronic cerebellar dysfunction
+**Cerebellar atrophy on MRI
+*'''JCV encephalitis'''
+**Subacute onset of encephalopathy
+**Cortical lesions on MRI
+*'''JCV meningitis'''
+**Chronic headaches
+**Ventriculomegaly on MRI
-== Investigations ==
+==Investigations==
-* MRI head: white matter changes
+*MRI head: white matter changes
+*CSF: fairly nonspecific, with mild pleocytosis, slightly elevated protein, and normal glucose
+**PCR of CSF has sensitivity 58% with ART or 72-92% without, and specificity 92-100%
-== Diagnosis ==
+==Diagnosis==
-* JC virus PCR
+*JC virus PCR of CSF or brain biopsy
-== Treatment ==
+==Treatment==
-* Antiretroviral therapy for HIV
+*Antiretroviral therapy for HIV
+[[Category:HIV]]
+[[Category:Polyomaviridae]]