Category:Prions: Difference between revisions
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Latest revision as of 10:16, 16 August 2019
- Proteinaceous infectious particles that are capable of self-propagating
- May be acquired by infection (iCJD and vCJD), sporadic mutation (sCJD and sFI), or heritable genetics (fCJD, GSS, and FFI)
- In human, prion disease generally refers to Creutzfeldt-Jakob disease and its subtypes, all caused by misfolding of PrPC, although there is some evidence that amyloidosis, Alzheimer disease, Parkinson disease, frontotemporal dementia, amyotrophic lateral sclerosis can be caused by self-propagating proteins
| Disease | Abbr | Host | Etiology |
|---|---|---|---|
| Human Prion Diseases | |||
| Kuru | — | human | ritualistic cannibalism in Papua New Guinea |
| sporadic Creutzfeldt-Jakob disease | sCJD | human | spontaneous mutation of PrPC to PrPSc |
| familial Creutzfeldt-Jakob disease | fCJD | human | mutations in PRNP gene |
| Gerstmann-Straüssler-Scheinker syndrome | GSS | human | mutations in PRNP gene |
| iatrogenic Creutzfeldt-Jakob disease | iCJD | human | infection from surgical exposure to sCJD |
| fatal familial insomnia | FFI | human | PRNP haplotype 178N-129M |
| variant Creutzfeldt-Jakob disease | vCJD | human | BSE origin |
| sporadic fatal insomnia | sFI | human | spontaneous mutation of PrPC to PrPSc |
| variably protease-sensitive prionopathy | VPSPr | human | spontaneous mutation of PrPC to PrPSc |
| Animal Prion Diseases | |||
| scrapie | — | sheep and goats | unknown origin |
| transmissible mink encephalopathy | TME | mink | sheep or cattle origin |
| chronic wasting disease | CWD | cervids | unknown origin |
| bovine spongiform encephalopathy | BSE | cattle | unknown origin |
| exotic ungulate spongiform encephalopathy | EUE | Nyala, Kudu | BSE origin |
| feline spongiform encephalopathy | FSE | cats | BSE origin |
| non-human primate spongiform encephalopathy | NHP | lemurs | BSE origin |
Pages in category "Prions"
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