Fusobacterium necrophorum: Difference between revisions
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Fusobacterium necrophorum
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Created page with "{{DISPLAYTITLE:''Fusobacterium necrophorum''}} == Background == * Anaerobic Stain::Gram-negative or Stain::Gram-variable Shape::bacillus within the genus Genus::Fusobacterium * Previously known as ''Bacillus necrophorus'' == Clinical Manifestations == * Odontogenic infections * Causative organism of Lemierre syndrome * Can spread hematogenously to bone and joint, muscles and soft tissue, liver, spleen, and endoc..." |
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* First-line options include [[piperacillin-tazobactam]], carbapenems, and [[metronidazole]] |
* First-line options include [[piperacillin-tazobactam]], carbapenems, and [[metronidazole]] |
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** Often need polymicrobial coverage, for this [[ceftriaxone]] plus [[metronidazole]] would be an excellent option |
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* May produce beta-lactamases, so shouldn't use penicillins without beta-lactamase inhibitors |
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* Patients with [[Lemierre syndrome]] can take more than a week to defervesce, despite appropriate antibiotics |
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== Further Reading == |
== Further Reading == |
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Latest revision as of 14:34, 17 February 2026
Background
- Anaerobic Gram-negative or Gram-variable bacillus within the genus Fusobacterium
- Previously known as Bacillus necrophorus
Clinical Manifestations
- Odontogenic infections
- Causative organism of Lemierre syndrome
- Can spread hematogenously to bone and joint, muscles and soft tissue, liver, spleen, and endocarditis
- Can cause peritonsillar abscess, deep neck space infections, and mediastinitis
- Has been implicated in venous sinus thrombophlebitis, meningitis, and brain abscess (the latter more often in polymicrobial infection and more commonly involves Fusobacterium nucleatum)
Management
- First-line options include piperacillin-tazobactam, carbapenems, and metronidazole
- Often need polymicrobial coverage, for this ceftriaxone plus metronidazole would be an excellent option
- May produce beta-lactamases, so shouldn't use penicillins without beta-lactamase inhibitors
- Patients with Lemierre syndrome can take more than a week to defervesce, despite appropriate antibiotics
Further Reading
- Human Infection with Fusobacterium necrophorum (Necrobacillosis) with a Focus on Lemierre Syndrome. Clin Microbiol Rev. 2007;20(4):622-659. doi 10.1128/CMR.00011-07
