Doxycycline: Difference between revisions
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* Can treat: {{#ask: [[Is treated by::doxycycline]]|default=none}} |
* Can treat: {{#ask: [[Is treated by::doxycycline]]|default=none}} |
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=== Pharmacokinetics and Pharmacodynamics === |
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=== Distribution === |
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* Absorption is good, around 80 to 90% |
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* Achieves only low concentrations in the urine, so generally not recommended for UTIs, though some debate about this[[CiteRef::jodlowski2020do]] |
* Achieves only low concentrations in the urine, so generally not recommended for UTIs, though some debate about this[[CiteRef::jodlowski2020do]] |
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* CSF concentration is 15-25% of serum, but with 200 mg twice daily dosing should be reliably above MIC for [[syphilis]] and [[Lyme disease]][[CiteRef::yim1985pe]][[CiteRef::dotevall1989pe]] |
* CSF concentration is 15-25% of serum, but with 200 mg twice daily dosing should be reliably above MIC for [[syphilis]] and [[Lyme disease]][[CiteRef::yim1985pe]][[CiteRef::dotevall1989pe]] |
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* Elimination half-life is 12 to 25 hours |
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== Dosing == |
== Dosing == |
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Latest revision as of 18:56, 3 February 2026
Background
- Tetracycline antibiotic
Spectrum of Activity
- Can treat: Actinomyces, Bacillary angiomatosis, Bartonella henselae, Borrelia miyamotoi, Brucella melitensis, Burkholderia mallei, Chlamydia trachomatis, Cutibacterium acnes, Enterococcus, Francisella tularensis, Legionella, Leptospira, Lymphogranuloma venereum, Mycoplasma genitalium, Pelvic inflammatory disease, Plasmodium, Rickettsia, Rickettsia africae, Rickettsia akari, Rickettsia conorii, Rickettsia prowazekii, Rickettsia rickettsii, Rickettsia typhi, Rickettsioses, Rickettsioses, Southern tick-associated rash illness, Stenotrophomonas maltophilia, Tick-borne relapsing fever, Treponema pallidum pallidum, Yersinia enterocolitica, Yersinia pestis
Pharmacokinetics and Pharmacodynamics
- Absorption is good, around 80 to 90%
- Achieves only low concentrations in the urine, so generally not recommended for UTIs, though some debate about this1
- CSF concentration is 15-25% of serum, but with 200 mg twice daily dosing should be reliably above MIC for syphilis and Lyme disease23
- Elimination half-life is 12 to 25 hours
Dosing
- Usual dosing 100 mg po BID
Safety
Adverse Effects
- Counsel on high risk of sun sensitivity and pill esophagitis
Pregnancy
- Generally avoid using in pregnant women and children less than 8 years of age due to bone and tooth staining
- However, can often tolerate short courses up to 5 days without issue
References
- ^ Tomasz Jodlowski, Charles R Ashby, Sarath G Nath. Doxycycline for ESBL-E Cystitis. Clinical Infectious Diseases. 2020. doi:10.1093/cid/ciaa1898.
