Cryptococcus (IDSA 2010): Difference between revisions
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Revision as of 01:14, 15 August 2019
Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update
Meningoencephalitis
HIV-infected
- Induction: AmBd 0.7-1 mg/kg/d IV plus flucytosine 100 mg/kg/d po split QID for at least 2 weeks
- Can use liposomal AmB 3–4 mg/kg/d IV or ABLC 5 mg/kg/d IV
- Can continue for 4-6 weeks if high fungal burden or failure to respond
- Can replace flucytosine with fluconazole 800-1200 mg daily for minimum of 8 weeks if needed
- Consolidation: fluconazole 400 mg daily for at least 8 weeks
- If high
