Rifampin: Difference between revisions
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** Weight <60 kg: 600 mg p.o. daily |
** Weight <60 kg: 600 mg p.o. daily |
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** Weight >60 kg: 450 mg p.o. twice daily |
** Weight >60 kg: 450 mg p.o. twice daily |
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== Safety == |
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=== Drug-Drug Interactions === |
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* Multiple |
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* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]] |
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[[Category:Rifamycins]] |
[[Category:Rifamycins]] |
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Revision as of 02:12, 23 October 2022
- Inhibits bacterial DNA-dependent RNA polymerase
- Never given alone due to rapid resistance
- Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
- Avoid in liver failure
Dosing
- As adjunct to fluoroquinolone for Staphylococcus aureus:
- Weight <60 kg: 600 mg p.o. daily
- Weight >60 kg: 450 mg p.o. twice daily
Safety
Drug-Drug Interactions
- Multiple
- Other antibiotics include clindamycin, doxycycline, linezolid, moxifloxacin, trimethoprim, and fusidic acid
References
- ^ Gousia Dhhar, Jeanine McColl, Ian Kitai, Deborah M. Levy, Ruud H.J. Verstegen. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. Canadian Medical Association Journal. 2023;195(34):E1151-E1153. doi:10.1503/cmaj.230317.
