Rifampin: Difference between revisions
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* Inhibits bacterial DNA-dependent RNA polymerase |
* Inhibits bacterial DNA-dependent RNA polymerase |
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* Never given alone due to rapid resistance |
* Never given alone due to rapid resistance |
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* Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia |
* Adverse effects include [[Adverse drug reaction::drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]] |
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* Avoid in liver failure |
* Avoid in liver failure |
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== Dosing == |
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* As adjunct to fluoroquinolone for [[Staphylococcus aureus]]: |
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** Weight <60 kg: 600 mg p.o. daily |
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** Weight >60 kg: 450 mg p.o. twice daily |
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== Safety == |
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=== Drug-Drug Interactions === |
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* Multiple |
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* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]] |
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[[Category:Rifamycins]] |
[[Category:Rifamycins]] |
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Revision as of 02:12, 23 October 2022
- Inhibits bacterial DNA-dependent RNA polymerase
- Never given alone due to rapid resistance
- Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
- Avoid in liver failure
Dosing
- As adjunct to fluoroquinolone for Staphylococcus aureus:
- Weight <60 kg: 600 mg p.o. daily
- Weight >60 kg: 450 mg p.o. twice daily
Safety
Drug-Drug Interactions
- Multiple
- Other antibiotics include clindamycin, doxycycline, linezolid, moxifloxacin, trimethoprim, and fusidic acid
