Nirmatrelvir-ritonavir: Difference between revisions
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* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset |
* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset |
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=== Renal Dosing === |
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* eGFR ≥60 mL/min: no adjustment |
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* eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid |
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* eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days |
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* Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days |
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=== Hepatic Dosing === |
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* [[Child-Pugh classification|Child-Pugh]] class C: contraindicated |
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[[Category:Medications]] |
[[Category:Medications]] |
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Latest revision as of 14:36, 24 July 2022
Dosing
- COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset
Renal Dosing
- eGFR ≥60 mL/min: no adjustment
- eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
- eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
- Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days
Hepatic Dosing
- Child-Pugh class C: contraindicated
