Hepatic encephalopathy: Difference between revisions

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== Grading ==

* '''Grade 0:''' no encephalopathy
** Normal consciousness, personality, neurological examination, and electroencephalogram
* '''Grade 1:''' changes in behaviour with minimal change in level of consciousness
** Restless, sleep disturbed, irritable/agitated, termor, impaired handwriting, 5 cps waves on EEG
* '''Grade 2:''' gross disorientation, drowsiness, possibly asterixis, inappropriate behaviour
** Lethargic, time-disoriented, inappropriate, asterixis, ataxia, slow triphasic waves on EEG
* '''Grade 3:''' marked confusion, incoherent speech, sleeping most of the time but arousable to vocal stimulus
** Somnolent, stuporous, place-disoriented, hyperactive reflexes, rigidity, slower waves on EEG
* '''Grade 4:''' comatose, unresponsive to pain, decorticate or decerebrate posturing
** Unrousable coma, no personality/behvaiour, decerebrate, slow 2-3 cps delta activity on EEG

== Investigations ==
== Investigations ==



Latest revision as of 18:01, 9 March 2022

Grading

  • Grade 0: no encephalopathy
    • Normal consciousness, personality, neurological examination, and electroencephalogram
  • Grade 1: changes in behaviour with minimal change in level of consciousness
    • Restless, sleep disturbed, irritable/agitated, termor, impaired handwriting, 5 cps waves on EEG
  • Grade 2: gross disorientation, drowsiness, possibly asterixis, inappropriate behaviour
    • Lethargic, time-disoriented, inappropriate, asterixis, ataxia, slow triphasic waves on EEG
  • Grade 3: marked confusion, incoherent speech, sleeping most of the time but arousable to vocal stimulus
    • Somnolent, stuporous, place-disoriented, hyperactive reflexes, rigidity, slower waves on EEG
  • Grade 4: comatose, unresponsive to pain, decorticate or decerebrate posturing
    • Unrousable coma, no personality/behvaiour, decerebrate, slow 2-3 cps delta activity on EEG

Investigations

  • In general, discourage measuring serum ammonia

Management

Acute

  • Lactulose

Chronic prophylaxis

  • Lactulose
  • Add-on: rifaximin
  • Reassess adherence
  • Assess for medications contributing to encephalopathy