Manogepix: Difference between revisions
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* Mechanism of action is as a small-molecule inhibitor of the conserved fungal Gwt1 protein, which is required for acylation of inositol during glycosylphosphatidylinositol anchor biosynthesis |
* Mechanism of action is as a small-molecule inhibitor of the conserved fungal Gwt1 protein, which is required for acylation of inositol during glycosylphosphatidylinositol anchor biosynthesis |
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* Prodrug is fosmanogepix |
* Prodrug is fosmanogepix |
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* Active against [[Candida |
* Active against [[Candida]] (except [[Candida krusei]]), [[Aspergillus]], [[Cryptococcus neoformans]], and other molds (such as [[Fusarium]] and [[Scedosporium]] |
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== Further Reading == |
== Further Reading == |
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Latest revision as of 13:46, 11 February 2022
Background
- Antifungal
- Mechanism of action is as a small-molecule inhibitor of the conserved fungal Gwt1 protein, which is required for acylation of inositol during glycosylphosphatidylinositol anchor biosynthesis
- Prodrug is fosmanogepix
- Active against Candida (except Candida krusei), Aspergillus, Cryptococcus neoformans, and other molds (such as Fusarium and Scedosporium
Further Reading
- Antimicrobial activity of manogepix, a first-in-class antifungal, and comparator agents tested against contemporary invasive fungal isolates from an international surveillance programme (2018-2019). J Glob Antimicrob Resist. 2021;26:117-127. doi: 10.1016/j.jgar.2021.04.012
